Inhalation Toxicology. 11. The Effect of Elevated Temperature on Carbon Monoxide Toxicity

Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 deg C to 60 deg C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency...

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description Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 deg C to 60 deg C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurements of time-to- incapacitation (t sub i) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated than incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted t sub i for combinations of CO and temperature within the rangers utilized in the experimental exposures.
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The Effect of Elevated Temperature on Carbon Monoxide Toxicity</title><source>DTIC Technical Reports</source><creator>Sanders, Donald C ; Endecott, Boyd R</creator><creatorcontrib>Sanders, Donald C ; Endecott, Boyd R ; FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROMEDICAL INST</creatorcontrib><description>Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 deg C to 60 deg C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurements of time-to- incapacitation (t sub i) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated than incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. 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The Effect of Elevated Temperature on Carbon Monoxide Toxicity</title><description>Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 deg C to 60 deg C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurements of time-to- incapacitation (t sub i) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated than incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted t sub i for combinations of CO and temperature within the rangers utilized in the experimental exposures.</description><subject>ATMOSPHERES</subject><subject>CARBON MONOXIDE</subject><subject>CHAMBERS</subject><subject>COMPARISON</subject><subject>EQUATIONS</subject><subject>EXPOSURE(GENERAL)</subject><subject>HEAT STRESS(PHYSIOLOGY)</subject><subject>HIGH TEMPERATURE</subject><subject>INCAPACITATION</subject><subject>INHALATION</subject><subject>LABORATORY ANIMALS</subject><subject>PARAMETERS</subject><subject>RATS</subject><subject>Stress Physiology</subject><subject>SYNERGISM</subject><subject>TOXICITY</subject><subject>Toxicology</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1990</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZIj0zMtIzEksyczPUwjJr8hMzs_JT6_UUzA01FMIyUhVcE1LS00uUchPU3DNSS1LLElNUQhJzS1ILUosKS1KVQDqck4sSgJSvvl5QO0pqRBTMksqeRhY0xJzilN5oTQ3g4yba4izh25KSWZyfHFJZl5qSbyji6ORsaGhhakxAWkA6Lg2hw</recordid><startdate>199012</startdate><enddate>199012</enddate><creator>Sanders, Donald C</creator><creator>Endecott, Boyd R</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>199012</creationdate><title>Inhalation Toxicology. 11. 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The Effect of Elevated Temperature on Carbon Monoxide Toxicity</btitle><date>1990-12</date><risdate>1990</risdate><abstract>Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 deg C to 60 deg C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurements of time-to- incapacitation (t sub i) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated than incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted t sub i for combinations of CO and temperature within the rangers utilized in the experimental exposures.</abstract><oa>free_for_read</oa></addata></record>
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source DTIC Technical Reports
subjects ATMOSPHERES
CARBON MONOXIDE
CHAMBERS
COMPARISON
EQUATIONS
EXPOSURE(GENERAL)
HEAT STRESS(PHYSIOLOGY)
HIGH TEMPERATURE
INCAPACITATION
INHALATION
LABORATORY ANIMALS
PARAMETERS
RATS
Stress Physiology
SYNERGISM
TOXICITY
Toxicology
title Inhalation Toxicology. 11. The Effect of Elevated Temperature on Carbon Monoxide Toxicity
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