The Determination of the Repeated Oral Toxicity of Halocarbon Oil, Series 27-S
Halocarbon 27-S (HC 27-S), a polymer of chlorotrifluoroethylene (CTFE), is used as a lubricating oil for pumps in hyperbaric chambers. Although monomeric CTFE has been shown to produce renal lesions in rats, the toxicity of CTFE polymers have been investigated. To assess the toxicity of repeated exp...
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| creator | Kinkead, Edwin R Culpepper, Brenda T Henry, Sandra S Szotak, Phyllis S Flemming, Caryle D |
| description | Halocarbon 27-S (HC 27-S), a polymer of chlorotrifluoroethylene (CTFE), is used as a lubricating oil for pumps in hyperbaric chambers. Although monomeric CTFE has been shown to produce renal lesions in rats, the toxicity of CTFE polymers have been investigated. To assess the toxicity of repeated exposure to HC 27-S, three groups of male and female Fischer-344 rats were dosed. Decreased water consumption and urine output were apparent in all test groups. Statistically significant increases in fluoride excretion were noted in 24-hr urine samples assessed periodically during the study. Neurotoxic signs were observed in female rats but not in male rats. Significant increases in liver and kidney weights were seen in all rats, regardless of number of dosing days. The increased fluoride burden in treated animals appeared sufficient to alter bone calcium/phosphate ratios in male rats but not female rats. Gross liver enlargement and hepatocellular cytomegaly indicated that the liver was probably the primary target organ following repeated administration of HC 27-S. Keywords: Oral toxicity, Halocarbon oil, Industrial health, Hyperbaric chambers, Fluoride, BUN, CAP, CTFE, F-344, HC 27-S, LDH, SEM, Reprints, Bone, Calcium, Phosphates, Rats.
Pub. Toxicology and Industrial Health, v6 n1 p17-32 1990. |
| format | Report |
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Pub. Toxicology and Industrial Health, v6 n1 p17-32 1990.</description><language>eng</language><subject>ANIMALS ; BONES ; BUN ; CALCIUM ; CAP ; CHLORINE TRIFLUORIDE ; CHLOROTRIFLUOROETHYLENE ; CONSUMPTION ; CTFE ; ETHYLENES ; EXCRETION ; F-344 ; FEMALES ; FLUORIDES ; HALOGENATED HYDROCARBONS ; HC 27-S ; HEALTH ; HYPERBARIC CHAMBERS ; INDUSTRIES ; KIDNEYS ; LDH ; LESIONS ; LIVER ; LUBRICATING OILS ; MALES ; NEUROTOXIC SIGNS ; OILS ; ORAL INTAKE ; OUTPUT ; PE63706N ; PHOSPHATES ; Polymer Chemistry ; POLYMERS ; PUMPS ; RATIOS ; RATS ; REPRINTS ; SEM ; TOXICITY ; Toxicology ; URINE ; WATER ; WEIGHT ; WU0006 ; WUDN377025</subject><creationdate>1990</creationdate><rights>Approved for public release; distribution is unlimited.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27567,27568</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA223526$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Kinkead, Edwin R</creatorcontrib><creatorcontrib>Culpepper, Brenda T</creatorcontrib><creatorcontrib>Henry, Sandra S</creatorcontrib><creatorcontrib>Szotak, Phyllis S</creatorcontrib><creatorcontrib>Flemming, Caryle D</creatorcontrib><creatorcontrib>NAVAL MEDICAL RESEARCH INST BETHESDA MD</creatorcontrib><title>The Determination of the Repeated Oral Toxicity of Halocarbon Oil, Series 27-S</title><description>Halocarbon 27-S (HC 27-S), a polymer of chlorotrifluoroethylene (CTFE), is used as a lubricating oil for pumps in hyperbaric chambers. Although monomeric CTFE has been shown to produce renal lesions in rats, the toxicity of CTFE polymers have been investigated. To assess the toxicity of repeated exposure to HC 27-S, three groups of male and female Fischer-344 rats were dosed. Decreased water consumption and urine output were apparent in all test groups. Statistically significant increases in fluoride excretion were noted in 24-hr urine samples assessed periodically during the study. Neurotoxic signs were observed in female rats but not in male rats. Significant increases in liver and kidney weights were seen in all rats, regardless of number of dosing days. The increased fluoride burden in treated animals appeared sufficient to alter bone calcium/phosphate ratios in male rats but not female rats. Gross liver enlargement and hepatocellular cytomegaly indicated that the liver was probably the primary target organ following repeated administration of HC 27-S. Keywords: Oral toxicity, Halocarbon oil, Industrial health, Hyperbaric chambers, Fluoride, BUN, CAP, CTFE, F-344, HC 27-S, LDH, SEM, Reprints, Bone, Calcium, Phosphates, Rats.
Pub. Toxicology and Industrial Health, v6 n1 p17-32 1990.</description><subject>ANIMALS</subject><subject>BONES</subject><subject>BUN</subject><subject>CALCIUM</subject><subject>CAP</subject><subject>CHLORINE TRIFLUORIDE</subject><subject>CHLOROTRIFLUOROETHYLENE</subject><subject>CONSUMPTION</subject><subject>CTFE</subject><subject>ETHYLENES</subject><subject>EXCRETION</subject><subject>F-344</subject><subject>FEMALES</subject><subject>FLUORIDES</subject><subject>HALOGENATED HYDROCARBONS</subject><subject>HC 27-S</subject><subject>HEALTH</subject><subject>HYPERBARIC CHAMBERS</subject><subject>INDUSTRIES</subject><subject>KIDNEYS</subject><subject>LDH</subject><subject>LESIONS</subject><subject>LIVER</subject><subject>LUBRICATING OILS</subject><subject>MALES</subject><subject>NEUROTOXIC SIGNS</subject><subject>OILS</subject><subject>ORAL INTAKE</subject><subject>OUTPUT</subject><subject>PE63706N</subject><subject>PHOSPHATES</subject><subject>Polymer Chemistry</subject><subject>POLYMERS</subject><subject>PUMPS</subject><subject>RATIOS</subject><subject>RATS</subject><subject>REPRINTS</subject><subject>SEM</subject><subject>TOXICITY</subject><subject>Toxicology</subject><subject>URINE</subject><subject>WATER</subject><subject>WEIGHT</subject><subject>WU0006</subject><subject>WUDN377025</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1990</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZPALyUhVcEktSS3KzcxLLMnMz1PIT1MoAQoGpRakJpakpij4FyXmKITkV2QmZ5ZUgmQ9EnPykxOLkoBq_TNzdBSCU4syU4sVjMx1g3kYWNMSc4pTeaE0N4OMm2uIs4duSklmcnxxSWZeakm8o4ujkZGxqZGZMQFpAD-DMco</recordid><startdate>199001</startdate><enddate>199001</enddate><creator>Kinkead, Edwin R</creator><creator>Culpepper, Brenda T</creator><creator>Henry, Sandra S</creator><creator>Szotak, Phyllis S</creator><creator>Flemming, Caryle D</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>199001</creationdate><title>The Determination of the Repeated Oral Toxicity of Halocarbon Oil, Series 27-S</title><author>Kinkead, Edwin R ; Culpepper, Brenda T ; Henry, Sandra S ; Szotak, Phyllis S ; Flemming, Caryle D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA2235263</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ANIMALS</topic><topic>BONES</topic><topic>BUN</topic><topic>CALCIUM</topic><topic>CAP</topic><topic>CHLORINE TRIFLUORIDE</topic><topic>CHLOROTRIFLUOROETHYLENE</topic><topic>CONSUMPTION</topic><topic>CTFE</topic><topic>ETHYLENES</topic><topic>EXCRETION</topic><topic>F-344</topic><topic>FEMALES</topic><topic>FLUORIDES</topic><topic>HALOGENATED HYDROCARBONS</topic><topic>HC 27-S</topic><topic>HEALTH</topic><topic>HYPERBARIC CHAMBERS</topic><topic>INDUSTRIES</topic><topic>KIDNEYS</topic><topic>LDH</topic><topic>LESIONS</topic><topic>LIVER</topic><topic>LUBRICATING OILS</topic><topic>MALES</topic><topic>NEUROTOXIC SIGNS</topic><topic>OILS</topic><topic>ORAL INTAKE</topic><topic>OUTPUT</topic><topic>PE63706N</topic><topic>PHOSPHATES</topic><topic>Polymer Chemistry</topic><topic>POLYMERS</topic><topic>PUMPS</topic><topic>RATIOS</topic><topic>RATS</topic><topic>REPRINTS</topic><topic>SEM</topic><topic>TOXICITY</topic><topic>Toxicology</topic><topic>URINE</topic><topic>WATER</topic><topic>WEIGHT</topic><topic>WU0006</topic><topic>WUDN377025</topic><toplevel>online_resources</toplevel><creatorcontrib>Kinkead, Edwin R</creatorcontrib><creatorcontrib>Culpepper, Brenda T</creatorcontrib><creatorcontrib>Henry, Sandra S</creatorcontrib><creatorcontrib>Szotak, Phyllis S</creatorcontrib><creatorcontrib>Flemming, Caryle D</creatorcontrib><creatorcontrib>NAVAL MEDICAL RESEARCH INST BETHESDA MD</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kinkead, Edwin R</au><au>Culpepper, Brenda T</au><au>Henry, Sandra S</au><au>Szotak, Phyllis S</au><au>Flemming, Caryle D</au><aucorp>NAVAL MEDICAL RESEARCH INST BETHESDA MD</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>The Determination of the Repeated Oral Toxicity of Halocarbon Oil, Series 27-S</btitle><date>1990-01</date><risdate>1990</risdate><abstract>Halocarbon 27-S (HC 27-S), a polymer of chlorotrifluoroethylene (CTFE), is used as a lubricating oil for pumps in hyperbaric chambers. Although monomeric CTFE has been shown to produce renal lesions in rats, the toxicity of CTFE polymers have been investigated. To assess the toxicity of repeated exposure to HC 27-S, three groups of male and female Fischer-344 rats were dosed. Decreased water consumption and urine output were apparent in all test groups. Statistically significant increases in fluoride excretion were noted in 24-hr urine samples assessed periodically during the study. Neurotoxic signs were observed in female rats but not in male rats. Significant increases in liver and kidney weights were seen in all rats, regardless of number of dosing days. The increased fluoride burden in treated animals appeared sufficient to alter bone calcium/phosphate ratios in male rats but not female rats. Gross liver enlargement and hepatocellular cytomegaly indicated that the liver was probably the primary target organ following repeated administration of HC 27-S. Keywords: Oral toxicity, Halocarbon oil, Industrial health, Hyperbaric chambers, Fluoride, BUN, CAP, CTFE, F-344, HC 27-S, LDH, SEM, Reprints, Bone, Calcium, Phosphates, Rats.
Pub. Toxicology and Industrial Health, v6 n1 p17-32 1990.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ANIMALS BONES BUN CALCIUM CAP CHLORINE TRIFLUORIDE CHLOROTRIFLUOROETHYLENE CONSUMPTION CTFE ETHYLENES EXCRETION F-344 FEMALES FLUORIDES HALOGENATED HYDROCARBONS HC 27-S HEALTH HYPERBARIC CHAMBERS INDUSTRIES KIDNEYS LDH LESIONS LIVER LUBRICATING OILS MALES NEUROTOXIC SIGNS OILS ORAL INTAKE OUTPUT PE63706N PHOSPHATES Polymer Chemistry POLYMERS PUMPS RATIOS RATS REPRINTS SEM TOXICITY Toxicology URINE WATER WEIGHT WU0006 WUDN377025 |
| title | The Determination of the Repeated Oral Toxicity of Halocarbon Oil, Series 27-S |
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