Investigation of Stress Induced Alterations in Neutrophil Function
The primary goal of our research is to investigate the effects of 1) psychological and physical stress in human subjects during and after a military medical field exercise and cold stress in a rat model on neutrophil functions, including cells ability to migrate, adhere, and undergo respiratory burs...
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| creator | Bowles, Charles A |
| description | The primary goal of our research is to investigate the effects of 1) psychological and physical stress in human subjects during and after a military medical field exercise and cold stress in a rat model on neutrophil functions, including cells ability to migrate, adhere, and undergo respiratory burst. The relationships among adrenal hormones, stress, and neutrophil function will also be investigated. The Bushmaster exercise, is required of all fourth year medical students at USUHS and is held three times each year. Because of limits on our ability to assay large numbers of samples of fresh blood, and because each exercise session may differ slightly, our strategy is to assess stress and neutrophil activity from several Bushmaster sessions and combine the data across a two-year period. The effect of cold stress on rats will be evaluated after four hours exposure to 4 C and compared to responses of rats maintained at 25 C. Because of the limited number of cells available from each rat, studies were conducted using neutrophils collected from blood pooled from 3-4 rats. (kt) |
| format | Report |
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The relationships among adrenal hormones, stress, and neutrophil function will also be investigated. The Bushmaster exercise, is required of all fourth year medical students at USUHS and is held three times each year. Because of limits on our ability to assay large numbers of samples of fresh blood, and because each exercise session may differ slightly, our strategy is to assess stress and neutrophil activity from several Bushmaster sessions and combine the data across a two-year period. The effect of cold stress on rats will be evaluated after four hours exposure to 4 C and compared to responses of rats maintained at 25 C. Because of the limited number of cells available from each rat, studies were conducted using neutrophils collected from blood pooled from 3-4 rats. (kt)</description><language>eng</language><subject>ADRENAL GLANDS ; ANATOMICAL MODELS ; ASSAYING ; BLOOD ; CELLS ; EXPOSURE(PHYSIOLOGY) ; FIELD CONDITIONS ; FUNCTIONS ; HORMONES ; LEUKOCYTES ; LOW TEMPERATURE ; MEDICINE ; MILITARY EXERCISES ; MILITARY MEDICINE ; NEUTROPHILE FUNCTION ; PE61153N ; POLYMORPHONUCLEAR NEUTROPHILS ; Psychology ; RATS ; RESPONSE ; Stress Physiology ; STRESS(PSYCHOLOGY) ; STRESSES ; STUDENTS</subject><creationdate>1990</creationdate><rights>Approved for public release; distribution is unlimited.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27567,27568</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA221177$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Bowles, Charles A</creatorcontrib><creatorcontrib>MERRIFIELD LABS INC VA</creatorcontrib><title>Investigation of Stress Induced Alterations in Neutrophil Function</title><description>The primary goal of our research is to investigate the effects of 1) psychological and physical stress in human subjects during and after a military medical field exercise and cold stress in a rat model on neutrophil functions, including cells ability to migrate, adhere, and undergo respiratory burst. The relationships among adrenal hormones, stress, and neutrophil function will also be investigated. The Bushmaster exercise, is required of all fourth year medical students at USUHS and is held three times each year. Because of limits on our ability to assay large numbers of samples of fresh blood, and because each exercise session may differ slightly, our strategy is to assess stress and neutrophil activity from several Bushmaster sessions and combine the data across a two-year period. The effect of cold stress on rats will be evaluated after four hours exposure to 4 C and compared to responses of rats maintained at 25 C. Because of the limited number of cells available from each rat, studies were conducted using neutrophils collected from blood pooled from 3-4 rats. (kt)</description><subject>ADRENAL GLANDS</subject><subject>ANATOMICAL MODELS</subject><subject>ASSAYING</subject><subject>BLOOD</subject><subject>CELLS</subject><subject>EXPOSURE(PHYSIOLOGY)</subject><subject>FIELD CONDITIONS</subject><subject>FUNCTIONS</subject><subject>HORMONES</subject><subject>LEUKOCYTES</subject><subject>LOW TEMPERATURE</subject><subject>MEDICINE</subject><subject>MILITARY EXERCISES</subject><subject>MILITARY MEDICINE</subject><subject>NEUTROPHILE FUNCTION</subject><subject>PE61153N</subject><subject>POLYMORPHONUCLEAR NEUTROPHILS</subject><subject>Psychology</subject><subject>RATS</subject><subject>RESPONSE</subject><subject>Stress Physiology</subject><subject>STRESS(PSYCHOLOGY)</subject><subject>STRESSES</subject><subject>STUDENTS</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1990</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZHDyzCtLLS7JTE8syczPU8hPUwguKUotLlbwzEspTU5NUXDMKUktAksWK2TmKfillpYU5RdkZOYouJXmJYPEeRhY0xJzilN5oTQ3g4yba4izh25KSWZyPNDsvNSSeEcXRyMjQ0Nzc2MC0gBs7y9z</recordid><startdate>19900423</startdate><enddate>19900423</enddate><creator>Bowles, Charles A</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>19900423</creationdate><title>Investigation of Stress Induced Alterations in Neutrophil Function</title><author>Bowles, Charles A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA2211773</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ADRENAL GLANDS</topic><topic>ANATOMICAL MODELS</topic><topic>ASSAYING</topic><topic>BLOOD</topic><topic>CELLS</topic><topic>EXPOSURE(PHYSIOLOGY)</topic><topic>FIELD CONDITIONS</topic><topic>FUNCTIONS</topic><topic>HORMONES</topic><topic>LEUKOCYTES</topic><topic>LOW TEMPERATURE</topic><topic>MEDICINE</topic><topic>MILITARY EXERCISES</topic><topic>MILITARY MEDICINE</topic><topic>NEUTROPHILE FUNCTION</topic><topic>PE61153N</topic><topic>POLYMORPHONUCLEAR NEUTROPHILS</topic><topic>Psychology</topic><topic>RATS</topic><topic>RESPONSE</topic><topic>Stress Physiology</topic><topic>STRESS(PSYCHOLOGY)</topic><topic>STRESSES</topic><topic>STUDENTS</topic><toplevel>online_resources</toplevel><creatorcontrib>Bowles, Charles A</creatorcontrib><creatorcontrib>MERRIFIELD LABS INC VA</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Bowles, Charles A</au><aucorp>MERRIFIELD LABS INC VA</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Investigation of Stress Induced Alterations in Neutrophil Function</btitle><date>1990-04-23</date><risdate>1990</risdate><abstract>The primary goal of our research is to investigate the effects of 1) psychological and physical stress in human subjects during and after a military medical field exercise and cold stress in a rat model on neutrophil functions, including cells ability to migrate, adhere, and undergo respiratory burst. The relationships among adrenal hormones, stress, and neutrophil function will also be investigated. The Bushmaster exercise, is required of all fourth year medical students at USUHS and is held three times each year. Because of limits on our ability to assay large numbers of samples of fresh blood, and because each exercise session may differ slightly, our strategy is to assess stress and neutrophil activity from several Bushmaster sessions and combine the data across a two-year period. The effect of cold stress on rats will be evaluated after four hours exposure to 4 C and compared to responses of rats maintained at 25 C. Because of the limited number of cells available from each rat, studies were conducted using neutrophils collected from blood pooled from 3-4 rats. (kt)</abstract><oa>free_for_read</oa></addata></record> |
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| source | DTIC Technical Reports |
| subjects | ADRENAL GLANDS ANATOMICAL MODELS ASSAYING BLOOD CELLS EXPOSURE(PHYSIOLOGY) FIELD CONDITIONS FUNCTIONS HORMONES LEUKOCYTES LOW TEMPERATURE MEDICINE MILITARY EXERCISES MILITARY MEDICINE NEUTROPHILE FUNCTION PE61153N POLYMORPHONUCLEAR NEUTROPHILS Psychology RATS RESPONSE Stress Physiology STRESS(PSYCHOLOGY) STRESSES STUDENTS |
| title | Investigation of Stress Induced Alterations in Neutrophil Function |
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