Are Reactive Oxygen Species Involved in Microcystin-LR Intoxication?

The toxic cyclic heptapeptide, microcystin-LR (cyanoginosin-LR, microcystin-A), isolated from the cyanobacterium Microcystis aeruginosa, kills mice within 1 hr after i.v. or i.p. exposure to an acute lethal dose. Hepatic engorgement and thrombocytopenia develop 30-40 min postchallenge. Histologic fi...

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Bibliographische Detailangaben
Hauptverfasser:	Franz, David R, LeClaire, Ross D, Lawrence, Wade B, Bunner, David L
Format:	Report
Sprache:	eng
Schlagworte:	ALLOXAN ANTIDOTES Biochemistry CHELATING AGENTS DEATH ENZYMES FREE RADICALS HEMORRHAGE IRON KIDNEY DISEASES KIDNEYS LESIONS LETHAL DOSAGE LIPIDS LIVER METABOLISM MICE MICROCYSTIS NECROSIS Pharmacology PSEUDOMONAS AERUGINOSA REACTIVITIES THROMBOCYTOPENIA TOXIC AGENTS TOXICITY Toxicology TOXINS AND ANTITOXINS
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