Evaluation of the Acute Toxicity of Selected Groundwater Contaminants
Acute dermal and inhalation toxicology studies were conducted on several selected groundwater contaminants to provide additional data for hazard evaluations by Air Force personnel. Four of the compounds; Tetrachloroethylene, 1,1,1 -Trichloroethane, Chlorobenzene, and 1,1-Dichloroethylene were tested...
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| creator | Kinkead, Edwin R Leahy, Harold F |
| description | Acute dermal and inhalation toxicology studies were conducted on several selected groundwater contaminants to provide additional data for hazard evaluations by Air Force personnel. Four of the compounds; Tetrachloroethylene, 1,1,1 -Trichloroethane, Chlorobenzene, and 1,1-Dichloroethylene were tested for acute dermal toxicity; 2,3-Dimethylphenol and 1,1-Dichloroethane were tested for acute 4-hour inhalation toxicity. Rabbits dermally treated with an upper limit dose of 2 ml/kg did not demonstrate symptoms of toxicity. Saturated vapors of 2, 3-Dimethylphenol did not result in mortality among exposed rats after 4 hours. However, 4-hour inhalation exposures to 1,1-Dichloroethane predicted an LC50 of approximately 13,000 ppm when using male rats. Keywords: Lethal concentration; Toxins. |
| format | Report |
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Four of the compounds; Tetrachloroethylene, 1,1,1 -Trichloroethane, Chlorobenzene, and 1,1-Dichloroethylene were tested for acute dermal toxicity; 2,3-Dimethylphenol and 1,1-Dichloroethane were tested for acute 4-hour inhalation toxicity. Rabbits dermally treated with an upper limit dose of 2 ml/kg did not demonstrate symptoms of toxicity. Saturated vapors of 2, 3-Dimethylphenol did not result in mortality among exposed rats after 4 hours. However, 4-hour inhalation exposures to 1,1-Dichloroethane predicted an LC50 of approximately 13,000 ppm when using male rats. Keywords: Lethal concentration; Toxins.</description><language>eng</language><subject>AIR FORCE PERSONNEL ; CHLORINE COMPOUNDS ; CHLOROBENZENE ; CONTAMINANTS ; DOSAGE ; ETHYLENES ; EXPOSURE(GENERAL) ; GROUND WATER ; HAZARDS ; LETHAL DOSAGE ; LIMITATIONS ; MALES ; PE62202F ; RABBITS ; RATS ; SIGNS AND SYMPTOMS ; SKIN(ANATOMY) ; TEST AND EVALUATION ; TETRACHLOROETHYLENE ; TOXICITY ; Toxicology ; TOXINS AND ANTITOXINS ; Water Pollution and Control ; WUAAMRL63020001</subject><creationdate>1987</creationdate><rights>APPROVED FOR PUBLIC RELEASE</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27567,27568</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA180198$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Kinkead, Edwin R</creatorcontrib><creatorcontrib>Leahy, Harold F</creatorcontrib><creatorcontrib>NORTHROP SERVICES INC - ENVIRONMENTAL SCIENCES DAYTON OH</creatorcontrib><title>Evaluation of the Acute Toxicity of Selected Groundwater Contaminants</title><description>Acute dermal and inhalation toxicology studies were conducted on several selected groundwater contaminants to provide additional data for hazard evaluations by Air Force personnel. Four of the compounds; Tetrachloroethylene, 1,1,1 -Trichloroethane, Chlorobenzene, and 1,1-Dichloroethylene were tested for acute dermal toxicity; 2,3-Dimethylphenol and 1,1-Dichloroethane were tested for acute 4-hour inhalation toxicity. Rabbits dermally treated with an upper limit dose of 2 ml/kg did not demonstrate symptoms of toxicity. Saturated vapors of 2, 3-Dimethylphenol did not result in mortality among exposed rats after 4 hours. However, 4-hour inhalation exposures to 1,1-Dichloroethane predicted an LC50 of approximately 13,000 ppm when using male rats. Keywords: Lethal concentration; Toxins.</description><subject>AIR FORCE PERSONNEL</subject><subject>CHLORINE COMPOUNDS</subject><subject>CHLOROBENZENE</subject><subject>CONTAMINANTS</subject><subject>DOSAGE</subject><subject>ETHYLENES</subject><subject>EXPOSURE(GENERAL)</subject><subject>GROUND WATER</subject><subject>HAZARDS</subject><subject>LETHAL DOSAGE</subject><subject>LIMITATIONS</subject><subject>MALES</subject><subject>PE62202F</subject><subject>RABBITS</subject><subject>RATS</subject><subject>SIGNS AND SYMPTOMS</subject><subject>SKIN(ANATOMY)</subject><subject>TEST AND EVALUATION</subject><subject>TETRACHLOROETHYLENE</subject><subject>TOXICITY</subject><subject>Toxicology</subject><subject>TOXINS AND ANTITOXINS</subject><subject>Water Pollution and Control</subject><subject>WUAAMRL63020001</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1987</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZHB1LUvMKU0syczPU8hPUyjJSFVwTC4tSVUIya_ITM4sqQSJBqfmpCaXpKYouBfll-allCeWpBYpOOfnlSTmZuYl5pUU8zCwpiXmFKfyQmluBhk31xBnD92Ukszk-OKSzLzUknhHF0dDCwNDSwtjAtIA5rcwWg</recordid><startdate>198704</startdate><enddate>198704</enddate><creator>Kinkead, Edwin R</creator><creator>Leahy, Harold F</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>198704</creationdate><title>Evaluation of the Acute Toxicity of Selected Groundwater Contaminants</title><author>Kinkead, Edwin R ; Leahy, Harold F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA1801983</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1987</creationdate><topic>AIR FORCE PERSONNEL</topic><topic>CHLORINE COMPOUNDS</topic><topic>CHLOROBENZENE</topic><topic>CONTAMINANTS</topic><topic>DOSAGE</topic><topic>ETHYLENES</topic><topic>EXPOSURE(GENERAL)</topic><topic>GROUND WATER</topic><topic>HAZARDS</topic><topic>LETHAL DOSAGE</topic><topic>LIMITATIONS</topic><topic>MALES</topic><topic>PE62202F</topic><topic>RABBITS</topic><topic>RATS</topic><topic>SIGNS AND SYMPTOMS</topic><topic>SKIN(ANATOMY)</topic><topic>TEST AND EVALUATION</topic><topic>TETRACHLOROETHYLENE</topic><topic>TOXICITY</topic><topic>Toxicology</topic><topic>TOXINS AND ANTITOXINS</topic><topic>Water Pollution and Control</topic><topic>WUAAMRL63020001</topic><toplevel>online_resources</toplevel><creatorcontrib>Kinkead, Edwin R</creatorcontrib><creatorcontrib>Leahy, Harold F</creatorcontrib><creatorcontrib>NORTHROP SERVICES INC - ENVIRONMENTAL SCIENCES DAYTON OH</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kinkead, Edwin R</au><au>Leahy, Harold F</au><aucorp>NORTHROP SERVICES INC - ENVIRONMENTAL SCIENCES DAYTON OH</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Evaluation of the Acute Toxicity of Selected Groundwater Contaminants</btitle><date>1987-04</date><risdate>1987</risdate><abstract>Acute dermal and inhalation toxicology studies were conducted on several selected groundwater contaminants to provide additional data for hazard evaluations by Air Force personnel. Four of the compounds; Tetrachloroethylene, 1,1,1 -Trichloroethane, Chlorobenzene, and 1,1-Dichloroethylene were tested for acute dermal toxicity; 2,3-Dimethylphenol and 1,1-Dichloroethane were tested for acute 4-hour inhalation toxicity. Rabbits dermally treated with an upper limit dose of 2 ml/kg did not demonstrate symptoms of toxicity. Saturated vapors of 2, 3-Dimethylphenol did not result in mortality among exposed rats after 4 hours. However, 4-hour inhalation exposures to 1,1-Dichloroethane predicted an LC50 of approximately 13,000 ppm when using male rats. Keywords: Lethal concentration; Toxins.</abstract><oa>free_for_read</oa></addata></record> |
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| source | DTIC Technical Reports |
| subjects | AIR FORCE PERSONNEL CHLORINE COMPOUNDS CHLOROBENZENE CONTAMINANTS DOSAGE ETHYLENES EXPOSURE(GENERAL) GROUND WATER HAZARDS LETHAL DOSAGE LIMITATIONS MALES PE62202F RABBITS RATS SIGNS AND SYMPTOMS SKIN(ANATOMY) TEST AND EVALUATION TETRACHLOROETHYLENE TOXICITY Toxicology TOXINS AND ANTITOXINS Water Pollution and Control WUAAMRL63020001 |
| title | Evaluation of the Acute Toxicity of Selected Groundwater Contaminants |
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