Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution
The goal of this project is to sequence the exomes of single tumor cells from tumors in order to construct evolutionary trees, the characteristics of which will be used to predict whether a tumor will metastasize or not. In the last project period, we have optimized tumor dissociation, tumor cell is...
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| creator | Patz, Edward Jr F |
| description | The goal of this project is to sequence the exomes of single tumor cells from tumors in order to construct evolutionary trees, the characteristics of which will be used to predict whether a tumor will metastasize or not. In the last project period, we have optimized tumor dissociation, tumor cell isolation, whole genome amplification, and exome sequencing. We have begun to sequence the exomes of single cells and to construct phylogenetic trees from the sequencing data. A sequencing pipeline has been established in order to obtain sufficient data with which to derive a prognostic classifier. |
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In the last project period, we have optimized tumor dissociation, tumor cell isolation, whole genome amplification, and exome sequencing. We have begun to sequence the exomes of single cells and to construct phylogenetic trees from the sequencing data. A sequencing pipeline has been established in order to obtain sufficient data with which to derive a prognostic classifier.</description><language>eng</language><subject>lung cancer ; Medicine and Medical Research ; metastasis ; neoplasms ; NSCLC (non-small cell lung cancer) ; Phylogenetic analysis ; Prognostic Markers ; SEQUENCE ANALYSIS ; tumor cells ; tumor evolution ; whole exome sequencing</subject><creationdate>2017</creationdate><rights>Approved For Public Release</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27565,27566</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/AD1044980$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Patz, Edward Jr F</creatorcontrib><creatorcontrib>Duke University Durham United States</creatorcontrib><title>Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution</title><description>The goal of this project is to sequence the exomes of single tumor cells from tumors in order to construct evolutionary trees, the characteristics of which will be used to predict whether a tumor will metastasize or not. In the last project period, we have optimized tumor dissociation, tumor cell isolation, whole genome amplification, and exome sequencing. We have begun to sequence the exomes of single cells and to construct phylogenetic trees from the sequencing data. A sequencing pipeline has been established in order to obtain sufficient data with which to derive a prognostic classifier.</description><subject>lung cancer</subject><subject>Medicine and Medical Research</subject><subject>metastasis</subject><subject>neoplasms</subject><subject>NSCLC (non-small cell lung cancer)</subject><subject>Phylogenetic analysis</subject><subject>Prognostic Markers</subject><subject>SEQUENCE ANALYSIS</subject><subject>tumor cells</subject><subject>tumor evolution</subject><subject>whole exome sequencing</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2017</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZAhxSS1LzckvyE3NK1HIT1NIVAgoyk_Pyy8uyUxW8E0syk4tUkjLL1LwKc1LV3BOzEsG8kOLM4Ecx7zEnMrizGKQrpDSXKAa17L8nNKSzPw8HgbWtMSc4lReKM3NIOPmGuLsoZsCNDUeaHReakm8o4uhgYmJpYWBMQFpAA5LNTA</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Patz, Edward Jr F</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>20170801</creationdate><title>Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution</title><author>Patz, Edward Jr F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_AD10449803</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2017</creationdate><topic>lung cancer</topic><topic>Medicine and Medical Research</topic><topic>metastasis</topic><topic>neoplasms</topic><topic>NSCLC (non-small cell lung cancer)</topic><topic>Phylogenetic analysis</topic><topic>Prognostic Markers</topic><topic>SEQUENCE ANALYSIS</topic><topic>tumor cells</topic><topic>tumor evolution</topic><topic>whole exome sequencing</topic><toplevel>online_resources</toplevel><creatorcontrib>Patz, Edward Jr F</creatorcontrib><creatorcontrib>Duke University Durham United States</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Patz, Edward Jr F</au><aucorp>Duke University Durham United States</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution</btitle><date>2017-08-01</date><risdate>2017</risdate><abstract>The goal of this project is to sequence the exomes of single tumor cells from tumors in order to construct evolutionary trees, the characteristics of which will be used to predict whether a tumor will metastasize or not. In the last project period, we have optimized tumor dissociation, tumor cell isolation, whole genome amplification, and exome sequencing. We have begun to sequence the exomes of single cells and to construct phylogenetic trees from the sequencing data. A sequencing pipeline has been established in order to obtain sufficient data with which to derive a prognostic classifier.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | DTIC Technical Reports |
| subjects | lung cancer Medicine and Medical Research metastasis neoplasms NSCLC (non-small cell lung cancer) Phylogenetic analysis Prognostic Markers SEQUENCE ANALYSIS tumor cells tumor evolution whole exome sequencing |
| title | Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution |
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