Female Rats are Less Susceptible during Puberty to Lethal Effects of Percutaneous Exposure to VX
Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to more easily penetrate through the skin. However,...
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| creator | Wright,Linnzi K Lee,Robyn B Clarkson,Edward D Lumley,Lucille A |
| description | Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to more easily penetrate through the skin. However, age-related differences in the lethal potency of VX have yet to be evaluated using the percutaneous (pc) route of exposure. Thus, we estimated the 24 and 48 h median lethal dose for pc exposure to VX in male and female rats during puberty and early adulthood. Pubescent, female rats were less susceptible than both their male and adult counterparts to the lethal effects associated with pc exposure to VX possibly because of hormonal changes during that stage of development. This study emphasizes the need to control for both age and sex when evaluating the toxicological effects associated with nerve agent exposure in the rat model
Toxicology Reports, 3, 01 Jan 0001, 01 Jan 0001, |
| format | Report |
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Toxicology Reports, 3, 01 Jan 0001, 01 Jan 0001,</description><language>eng</language><subject>Anatomy and Physiology ; Chemical, Biological and Radiological Warfare ; EXPOSURE (PHYSIOLOGY) ; females ; lethality ; median lethal dose ; nerve agents ; pc (percutaneous) ; pc exposure ; puberty ; rats ; stratum corneum ; toxicology ; VX AGENT</subject><creationdate>2015</creationdate><rights>Approved For Public Release</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,776,881,27544,27545</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/AD1025162$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Wright,Linnzi K</creatorcontrib><creatorcontrib>Lee,Robyn B</creatorcontrib><creatorcontrib>Clarkson,Edward D</creatorcontrib><creatorcontrib>Lumley,Lucille A</creatorcontrib><creatorcontrib>U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground United States</creatorcontrib><title>Female Rats are Less Susceptible during Puberty to Lethal Effects of Percutaneous Exposure to VX</title><description>Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to more easily penetrate through the skin. However, age-related differences in the lethal potency of VX have yet to be evaluated using the percutaneous (pc) route of exposure. Thus, we estimated the 24 and 48 h median lethal dose for pc exposure to VX in male and female rats during puberty and early adulthood. Pubescent, female rats were less susceptible than both their male and adult counterparts to the lethal effects associated with pc exposure to VX possibly because of hormonal changes during that stage of development. This study emphasizes the need to control for both age and sex when evaluating the toxicological effects associated with nerve agent exposure in the rat model
Toxicology Reports, 3, 01 Jan 0001, 01 Jan 0001,</description><subject>Anatomy and Physiology</subject><subject>Chemical, Biological and Radiological Warfare</subject><subject>EXPOSURE (PHYSIOLOGY)</subject><subject>females</subject><subject>lethality</subject><subject>median lethal dose</subject><subject>nerve agents</subject><subject>pc (percutaneous)</subject><subject>pc exposure</subject><subject>puberty</subject><subject>rats</subject><subject>stratum corneum</subject><subject>toxicology</subject><subject>VX AGENT</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2015</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNqFjLEKwjAURbs4iPoHDu8HBFvRXTTFwaGoiFtN0xcNxKTkvQf692Zwd7rDOeeOi3uNL-0RTpoJdEI4IhGchQwO7LpMekkuPKCRDhN_gGNW-Kk9KGvR5CpaaDAZYR0wCoF6D5EkX2X1epsWI6s94ey3k2Jeq8vusOjZmZbYBeR2uy-X1brcVKs_-AvpbTlp</recordid><startdate>20151217</startdate><enddate>20151217</enddate><creator>Wright,Linnzi K</creator><creator>Lee,Robyn B</creator><creator>Clarkson,Edward D</creator><creator>Lumley,Lucille A</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>20151217</creationdate><title>Female Rats are Less Susceptible during Puberty to Lethal Effects of Percutaneous Exposure to VX</title><author>Wright,Linnzi K ; Lee,Robyn B ; Clarkson,Edward D ; Lumley,Lucille A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_AD10251623</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anatomy and Physiology</topic><topic>Chemical, Biological and Radiological Warfare</topic><topic>EXPOSURE (PHYSIOLOGY)</topic><topic>females</topic><topic>lethality</topic><topic>median lethal dose</topic><topic>nerve agents</topic><topic>pc (percutaneous)</topic><topic>pc exposure</topic><topic>puberty</topic><topic>rats</topic><topic>stratum corneum</topic><topic>toxicology</topic><topic>VX AGENT</topic><toplevel>online_resources</toplevel><creatorcontrib>Wright,Linnzi K</creatorcontrib><creatorcontrib>Lee,Robyn B</creatorcontrib><creatorcontrib>Clarkson,Edward D</creatorcontrib><creatorcontrib>Lumley,Lucille A</creatorcontrib><creatorcontrib>U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground United States</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wright,Linnzi K</au><au>Lee,Robyn B</au><au>Clarkson,Edward D</au><au>Lumley,Lucille A</au><aucorp>U.S. Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground United States</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Female Rats are Less Susceptible during Puberty to Lethal Effects of Percutaneous Exposure to VX</btitle><date>2015-12-17</date><risdate>2015</risdate><abstract>Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to more easily penetrate through the skin. However, age-related differences in the lethal potency of VX have yet to be evaluated using the percutaneous (pc) route of exposure. Thus, we estimated the 24 and 48 h median lethal dose for pc exposure to VX in male and female rats during puberty and early adulthood. Pubescent, female rats were less susceptible than both their male and adult counterparts to the lethal effects associated with pc exposure to VX possibly because of hormonal changes during that stage of development. This study emphasizes the need to control for both age and sex when evaluating the toxicological effects associated with nerve agent exposure in the rat model
Toxicology Reports, 3, 01 Jan 0001, 01 Jan 0001,</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | Anatomy and Physiology Chemical, Biological and Radiological Warfare EXPOSURE (PHYSIOLOGY) females lethality median lethal dose nerve agents pc (percutaneous) pc exposure puberty rats stratum corneum toxicology VX AGENT |
| title | Female Rats are Less Susceptible during Puberty to Lethal Effects of Percutaneous Exposure to VX |
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