Dithionite Tube Test - A Rapid, Inexpensive Technique for the Detection of Hemoglobin S and Non-S Sickling Hemoglobin
An extensive field trial of the dithionite and the urea-dithionite tube tests indicates that the molecular theories of this method are supported by actual clinical tests. It is demonstrated that blood specimens appropriately collected at one site can be mailed at ambient temperatures for subsequent...
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| creator | Nalbandian,Robert M Nichols,Bruce M Camp,Frank R , Jr Lusher,Jeanne M Conte,Nicholas F |
| description | An extensive field trial of the dithionite and the urea-dithionite tube tests indicates that the molecular theories of this method are supported by actual clinical tests. It is demonstrated that blood specimens appropriately collected at one site can be mailed at ambient temperatures for subsequent processing at a geographically remote laboratory without adverse effect on the accuracy or reliability of the test. The test, performed in 5 minutes, has a reagent cost of about 2 cents per determination. It is of considerable interest that these testing techniques will detect not only hemoglobins S and C (Harlem), a structural variant of S, but other non-S sickling hemoglobins such as Bart's, C (Georgetown), and perhaps Alexandra and rare hemoglobinopathies of low solubility such as Kings County and Stanleyville II. The dithionite and urea-dithionite tests, however, will provide rapid, accurate, reliable, and inexpensive screening for hemoglobin S. (Author) |
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It is demonstrated that blood specimens appropriately collected at one site can be mailed at ambient temperatures for subsequent processing at a geographically remote laboratory without adverse effect on the accuracy or reliability of the test. The test, performed in 5 minutes, has a reagent cost of about 2 cents per determination. It is of considerable interest that these testing techniques will detect not only hemoglobins S and C (Harlem), a structural variant of S, but other non-S sickling hemoglobins such as Bart's, C (Georgetown), and perhaps Alexandra and rare hemoglobinopathies of low solubility such as Kings County and Stanleyville II. The dithionite and urea-dithionite tests, however, will provide rapid, accurate, reliable, and inexpensive screening for hemoglobin S. (Author)</description><language>eng</language><subject>ANEMIAS ; BLOOD DISEASES ; DETECTION ; DIAGNOSIS(GENERAL) ; DITHIONITE TEST ; EFFICIENCY ; HEMOGLOBIN ; HEMOGLOBIN S ; Medicine and Medical Research ; SCREENING TESTS ; SICKLE CELL ANEMIA ; SULFUR COMPOUNDS ; TEST METHODS ; UREA</subject><creationdate>1971</creationdate><rights>APPROVED FOR PUBLIC RELEASE</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27567,27568</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/AD0732356$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Nalbandian,Robert M</creatorcontrib><creatorcontrib>Nichols,Bruce M</creatorcontrib><creatorcontrib>Camp,Frank R , Jr</creatorcontrib><creatorcontrib>Lusher,Jeanne M</creatorcontrib><creatorcontrib>Conte,Nicholas F</creatorcontrib><creatorcontrib>ARMY MEDICAL RESEARCH LAB FORT KNOX KY</creatorcontrib><title>Dithionite Tube Test - A Rapid, Inexpensive Technique for the Detection of Hemoglobin S and Non-S Sickling Hemoglobin</title><description>An extensive field trial of the dithionite and the urea-dithionite tube tests indicates that the molecular theories of this method are supported by actual clinical tests. It is demonstrated that blood specimens appropriately collected at one site can be mailed at ambient temperatures for subsequent processing at a geographically remote laboratory without adverse effect on the accuracy or reliability of the test. The test, performed in 5 minutes, has a reagent cost of about 2 cents per determination. It is of considerable interest that these testing techniques will detect not only hemoglobins S and C (Harlem), a structural variant of S, but other non-S sickling hemoglobins such as Bart's, C (Georgetown), and perhaps Alexandra and rare hemoglobinopathies of low solubility such as Kings County and Stanleyville II. The dithionite and urea-dithionite tests, however, will provide rapid, accurate, reliable, and inexpensive screening for hemoglobin S. (Author)</description><subject>ANEMIAS</subject><subject>BLOOD DISEASES</subject><subject>DETECTION</subject><subject>DIAGNOSIS(GENERAL)</subject><subject>DITHIONITE TEST</subject><subject>EFFICIENCY</subject><subject>HEMOGLOBIN</subject><subject>HEMOGLOBIN S</subject><subject>Medicine and Medical Research</subject><subject>SCREENING TESTS</subject><subject>SICKLE CELL ANEMIA</subject><subject>SULFUR COMPOUNDS</subject><subject>TEST METHODS</subject><subject>UREA</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1971</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNqFyzEOglAQhGEaC6PewGIOIImRKDURDTYWQk_gscBG3Ie-xXh8MbGws5m_-DJTb4hZW7bCSsiGchxyCh8RLkXP1QonoVdP4vj5MdMK3wdCbR_QlhCTktHxD1sjoZttOluyIEUhFc5W_BQpm2vH0vz43JvURedo8e3MWx4P2T7xK2WTO2UhzaN4HQabYLsL_vAb16Q_8g</recordid><startdate>19710804</startdate><enddate>19710804</enddate><creator>Nalbandian,Robert M</creator><creator>Nichols,Bruce M</creator><creator>Camp,Frank R , Jr</creator><creator>Lusher,Jeanne M</creator><creator>Conte,Nicholas F</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>19710804</creationdate><title>Dithionite Tube Test - A Rapid, Inexpensive Technique for the Detection of Hemoglobin S and Non-S Sickling Hemoglobin</title><author>Nalbandian,Robert M ; Nichols,Bruce M ; Camp,Frank R , Jr ; Lusher,Jeanne M ; Conte,Nicholas F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_AD07323563</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1971</creationdate><topic>ANEMIAS</topic><topic>BLOOD DISEASES</topic><topic>DETECTION</topic><topic>DIAGNOSIS(GENERAL)</topic><topic>DITHIONITE TEST</topic><topic>EFFICIENCY</topic><topic>HEMOGLOBIN</topic><topic>HEMOGLOBIN S</topic><topic>Medicine and Medical Research</topic><topic>SCREENING TESTS</topic><topic>SICKLE CELL ANEMIA</topic><topic>SULFUR COMPOUNDS</topic><topic>TEST METHODS</topic><topic>UREA</topic><toplevel>online_resources</toplevel><creatorcontrib>Nalbandian,Robert M</creatorcontrib><creatorcontrib>Nichols,Bruce M</creatorcontrib><creatorcontrib>Camp,Frank R , Jr</creatorcontrib><creatorcontrib>Lusher,Jeanne M</creatorcontrib><creatorcontrib>Conte,Nicholas F</creatorcontrib><creatorcontrib>ARMY MEDICAL RESEARCH LAB FORT KNOX KY</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Nalbandian,Robert M</au><au>Nichols,Bruce M</au><au>Camp,Frank R , Jr</au><au>Lusher,Jeanne M</au><au>Conte,Nicholas F</au><aucorp>ARMY MEDICAL RESEARCH LAB FORT KNOX KY</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Dithionite Tube Test - A Rapid, Inexpensive Technique for the Detection of Hemoglobin S and Non-S Sickling Hemoglobin</btitle><date>1971-08-04</date><risdate>1971</risdate><abstract>An extensive field trial of the dithionite and the urea-dithionite tube tests indicates that the molecular theories of this method are supported by actual clinical tests. 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| subjects | ANEMIAS BLOOD DISEASES DETECTION DIAGNOSIS(GENERAL) DITHIONITE TEST EFFICIENCY HEMOGLOBIN HEMOGLOBIN S Medicine and Medical Research SCREENING TESTS SICKLE CELL ANEMIA SULFUR COMPOUNDS TEST METHODS UREA |
| title | Dithionite Tube Test - A Rapid, Inexpensive Technique for the Detection of Hemoglobin S and Non-S Sickling Hemoglobin |
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