INVESTIGATION OF NEPHROTOXIC EFFECTS OF ADENINE AND ITS METABOLIC PRODUCT, 2,8-DIOXYADENINE, ON PRIMATES (MACACA IRUS)
Primates injected with one 10 mg/kg dose of adenine over 10 min or the same dose daily for 5 days had no changes in renal function or structure. Single doses of 25 or 50 mg/kg produced decreases in renal plasma flow and/or glomerular filtration which appeared to be dose related. No crystalline depos...
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| creator | Shields,Charles E Lopas,Harry Birndorf,Norman I |
| description | Primates injected with one 10 mg/kg dose of adenine over 10 min or the same dose daily for 5 days had no changes in renal function or structure. Single doses of 25 or 50 mg/kg produced decreases in renal plasma flow and/or glomerular filtration which appeared to be dose related. No crystalline deposition or pathological changes were observed in the renal tissue at any dose level. Transient crystalluria was observed in some animals at the time of urinary adenine and 2,8-dioxyadenine excretion, but these crystals were not definitely identified. Adenine and 2,8-dioxyadenine were present in the urine at all dose levels during the first day, but were absent 24 hr after injection. (Author) |
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Single doses of 25 or 50 mg/kg produced decreases in renal plasma flow and/or glomerular filtration which appeared to be dose related. No crystalline deposition or pathological changes were observed in the renal tissue at any dose level. Transient crystalluria was observed in some animals at the time of urinary adenine and 2,8-dioxyadenine excretion, but these crystals were not definitely identified. Adenine and 2,8-dioxyadenine were present in the urine at all dose levels during the first day, but were absent 24 hr after injection. (Author)</description><language>eng</language><subject>ADENINE ; CHEMOTHERAPEUTIC AGENTS ; DAMAGE ; KETONES ; KIDNEYS ; METABOLISM ; PRIMATES ; TOXICITY ; Toxicology ; URIC ACID ; URINE ; XANTHINES</subject><creationdate>1970</creationdate><rights>APPROVED FOR PUBLIC RELEASE</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27566,27567</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/AD0705554$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Shields,Charles E</creatorcontrib><creatorcontrib>Lopas,Harry</creatorcontrib><creatorcontrib>Birndorf,Norman I</creatorcontrib><creatorcontrib>ARMY MEDICAL RESEARCH LAB FORT KNOX KY</creatorcontrib><title>INVESTIGATION OF NEPHROTOXIC EFFECTS OF ADENINE AND ITS METABOLIC PRODUCT, 2,8-DIOXYADENINE, ON PRIMATES (MACACA IRUS)</title><description>Primates injected with one 10 mg/kg dose of adenine over 10 min or the same dose daily for 5 days had no changes in renal function or structure. Single doses of 25 or 50 mg/kg produced decreases in renal plasma flow and/or glomerular filtration which appeared to be dose related. No crystalline deposition or pathological changes were observed in the renal tissue at any dose level. Transient crystalluria was observed in some animals at the time of urinary adenine and 2,8-dioxyadenine excretion, but these crystals were not definitely identified. Adenine and 2,8-dioxyadenine were present in the urine at all dose levels during the first day, but were absent 24 hr after injection. (Author)</description><subject>ADENINE</subject><subject>CHEMOTHERAPEUTIC AGENTS</subject><subject>DAMAGE</subject><subject>KETONES</subject><subject>KIDNEYS</subject><subject>METABOLISM</subject><subject>PRIMATES</subject><subject>TOXICITY</subject><subject>Toxicology</subject><subject>URIC ACID</subject><subject>URINE</subject><subject>XANTHINES</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1970</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNqFjLEKwjAURbs4iPoHDm9UaKGoRdeYvNgHNinJq9SpiFYoiEuL32-E7nKHC-ce7jT6kLmgZzoJJmvAajBY5s6yrUkCao2S_Q8LhYYMgjAKKKACWRztOUils6qSHMMmPiSKbH0d3RjCY-moEIweVoWQIUCu8ut5NHneXn27GHsWLTWyzJPH0N2bfuje7dAIle7TLMt22z_zF6RTNbw</recordid><startdate>19700121</startdate><enddate>19700121</enddate><creator>Shields,Charles E</creator><creator>Lopas,Harry</creator><creator>Birndorf,Norman I</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>19700121</creationdate><title>INVESTIGATION OF NEPHROTOXIC EFFECTS OF ADENINE AND ITS METABOLIC PRODUCT, 2,8-DIOXYADENINE, ON PRIMATES (MACACA IRUS)</title><author>Shields,Charles E ; Lopas,Harry ; Birndorf,Norman I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_AD07055543</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1970</creationdate><topic>ADENINE</topic><topic>CHEMOTHERAPEUTIC AGENTS</topic><topic>DAMAGE</topic><topic>KETONES</topic><topic>KIDNEYS</topic><topic>METABOLISM</topic><topic>PRIMATES</topic><topic>TOXICITY</topic><topic>Toxicology</topic><topic>URIC ACID</topic><topic>URINE</topic><topic>XANTHINES</topic><toplevel>online_resources</toplevel><creatorcontrib>Shields,Charles E</creatorcontrib><creatorcontrib>Lopas,Harry</creatorcontrib><creatorcontrib>Birndorf,Norman I</creatorcontrib><creatorcontrib>ARMY MEDICAL RESEARCH LAB FORT KNOX KY</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Shields,Charles E</au><au>Lopas,Harry</au><au>Birndorf,Norman I</au><aucorp>ARMY MEDICAL RESEARCH LAB FORT KNOX KY</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>INVESTIGATION OF NEPHROTOXIC EFFECTS OF ADENINE AND ITS METABOLIC PRODUCT, 2,8-DIOXYADENINE, ON PRIMATES (MACACA IRUS)</btitle><date>1970-01-21</date><risdate>1970</risdate><abstract>Primates injected with one 10 mg/kg dose of adenine over 10 min or the same dose daily for 5 days had no changes in renal function or structure. Single doses of 25 or 50 mg/kg produced decreases in renal plasma flow and/or glomerular filtration which appeared to be dose related. No crystalline deposition or pathological changes were observed in the renal tissue at any dose level. Transient crystalluria was observed in some animals at the time of urinary adenine and 2,8-dioxyadenine excretion, but these crystals were not definitely identified. Adenine and 2,8-dioxyadenine were present in the urine at all dose levels during the first day, but were absent 24 hr after injection. (Author)</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ADENINE CHEMOTHERAPEUTIC AGENTS DAMAGE KETONES KIDNEYS METABOLISM PRIMATES TOXICITY Toxicology URIC ACID URINE XANTHINES |
| title | INVESTIGATION OF NEPHROTOXIC EFFECTS OF ADENINE AND ITS METABOLIC PRODUCT, 2,8-DIOXYADENINE, ON PRIMATES (MACACA IRUS) |
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