BLOOD PLASMA LEVELS AND ELIMINATION OF SALTS OF 2-PAM IN MAN AFTER ORAL ADMINISTRATION
Adult male volunteers were given, orally, aqueous solutions of each of the chloride, iodide, dihydrogen phosphate, methane sulfonate, and lactate salts of 2-PAM in varying amounts. A measurable amount of oxime was found in blood plasma within about 15 minutes; the concentration rose rapidly, reached...
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creator | Kondritzer,Albert A Zvirblis,Peter Goodman,A Paplanus,S H |
description | Adult male volunteers were given, orally, aqueous solutions of each of the chloride, iodide, dihydrogen phosphate, methane sulfonate, and lactate salts of 2-PAM in varying amounts. A measurable amount of oxime was found in blood plasma within about 15 minutes; the concentration rose rapidly, reached a peak at 2 to 3 hours, and then declined at a rate that approximated a first-order process. The rates of absorption into and elimination from plasma of 2-PAMCl and P2S were practically identical. The equation, log Y = 0.79 + 0.54 log X, gives an approximate relationship between peak plasma levels of oxime (Y) and oral doses (X) of the various salts. Accordingly, a 10-fold increase in dosage of the 2-PAM salts increased the peak plasma level of oxime 3.5 fold. The biological half-life in man of the 2-PAM salts given orally, calculated from blood plasma values and urinary excretion rates, was 1.7 hours, with a coefficient of variation of 24%. The average total amount of 2-PAM recovered in the urine was 27%; the standard deviation of individual recoveries was 9%. Considerably less EA 1814 is excreted via the urine; an average of 3% was recovered during 24 hours among three subjects. Clinical changes observed were: (1) iodism symptoms in subjects given 2-PAM and (2) a 20% decrease in both RBC and plasma cholinesterase in subjects given 1 gm/70 kg of EA 1814. All other clinical tests were negative. (Author) |
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A measurable amount of oxime was found in blood plasma within about 15 minutes; the concentration rose rapidly, reached a peak at 2 to 3 hours, and then declined at a rate that approximated a first-order process. The rates of absorption into and elimination from plasma of 2-PAMCl and P2S were practically identical. The equation, log Y = 0.79 + 0.54 log X, gives an approximate relationship between peak plasma levels of oxime (Y) and oral doses (X) of the various salts. Accordingly, a 10-fold increase in dosage of the 2-PAM salts increased the peak plasma level of oxime 3.5 fold. The biological half-life in man of the 2-PAM salts given orally, calculated from blood plasma values and urinary excretion rates, was 1.7 hours, with a coefficient of variation of 24%. The average total amount of 2-PAM recovered in the urine was 27%; the standard deviation of individual recoveries was 9%. Considerably less EA 1814 is excreted via the urine; an average of 3% was recovered during 24 hours among three subjects. Clinical changes observed were: (1) iodism symptoms in subjects given 2-PAM and (2) a 20% decrease in both RBC and plasma cholinesterase in subjects given 1 gm/70 kg of EA 1814. All other clinical tests were negative. (Author)</description><language>eng</language><subject>Biochemistry ; BIOLOGICAL ABSORPTION ; BLOOD CHEMISTRY ; Chemical, Biological and Radiological Warfare ; CHOLINESTERASE INHIBITORS ; DETOXIFICATION ; DOSAGE ; EA 1814 AGENT ; EXCRETION ; OXIMES ; PYRIDINE ALDOXIME METHOCHLORIDE ; PYRIDINE ALDOXIMES ; URINE</subject><creationdate>1968</creationdate><rights>APPROVED FOR PUBLIC RELEASE</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27567,27568</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/AD0670932$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Kondritzer,Albert A</creatorcontrib><creatorcontrib>Zvirblis,Peter</creatorcontrib><creatorcontrib>Goodman,A</creatorcontrib><creatorcontrib>Paplanus,S H</creatorcontrib><creatorcontrib>EDGEWOOD ARSENAL MD</creatorcontrib><title>BLOOD PLASMA LEVELS AND ELIMINATION OF SALTS OF 2-PAM IN MAN AFTER ORAL ADMINISTRATION</title><description>Adult male volunteers were given, orally, aqueous solutions of each of the chloride, iodide, dihydrogen phosphate, methane sulfonate, and lactate salts of 2-PAM in varying amounts. A measurable amount of oxime was found in blood plasma within about 15 minutes; the concentration rose rapidly, reached a peak at 2 to 3 hours, and then declined at a rate that approximated a first-order process. The rates of absorption into and elimination from plasma of 2-PAMCl and P2S were practically identical. The equation, log Y = 0.79 + 0.54 log X, gives an approximate relationship between peak plasma levels of oxime (Y) and oral doses (X) of the various salts. Accordingly, a 10-fold increase in dosage of the 2-PAM salts increased the peak plasma level of oxime 3.5 fold. The biological half-life in man of the 2-PAM salts given orally, calculated from blood plasma values and urinary excretion rates, was 1.7 hours, with a coefficient of variation of 24%. The average total amount of 2-PAM recovered in the urine was 27%; the standard deviation of individual recoveries was 9%. Considerably less EA 1814 is excreted via the urine; an average of 3% was recovered during 24 hours among three subjects. Clinical changes observed were: (1) iodism symptoms in subjects given 2-PAM and (2) a 20% decrease in both RBC and plasma cholinesterase in subjects given 1 gm/70 kg of EA 1814. All other clinical tests were negative. (Author)</description><subject>Biochemistry</subject><subject>BIOLOGICAL ABSORPTION</subject><subject>BLOOD CHEMISTRY</subject><subject>Chemical, Biological and Radiological Warfare</subject><subject>CHOLINESTERASE INHIBITORS</subject><subject>DETOXIFICATION</subject><subject>DOSAGE</subject><subject>EA 1814 AGENT</subject><subject>EXCRETION</subject><subject>OXIMES</subject><subject>PYRIDINE ALDOXIME METHOCHLORIDE</subject><subject>PYRIDINE ALDOXIMES</subject><subject>URINE</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1968</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZAhz8vH3d1EI8HEM9nVU8HENc_UJVnD0c1Fw9fH09fRzDPH091Pwd1MIdvQJCQYxjHQDHH0VPP0UfB39FBzdQlyDFPyDHH0UHF2Ayj2DQ4LAWngYWNMSc4pTeaE0N4OMm2uIs4duSklmcnxxSWZeakm8o4uBmbmBpbGRMQFpAFdsLRk</recordid><startdate>196806</startdate><enddate>196806</enddate><creator>Kondritzer,Albert A</creator><creator>Zvirblis,Peter</creator><creator>Goodman,A</creator><creator>Paplanus,S H</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>196806</creationdate><title>BLOOD PLASMA LEVELS AND ELIMINATION OF SALTS OF 2-PAM IN MAN AFTER ORAL ADMINISTRATION</title><author>Kondritzer,Albert A ; Zvirblis,Peter ; Goodman,A ; Paplanus,S H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_AD06709323</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Biochemistry</topic><topic>BIOLOGICAL ABSORPTION</topic><topic>BLOOD CHEMISTRY</topic><topic>Chemical, Biological and Radiological Warfare</topic><topic>CHOLINESTERASE INHIBITORS</topic><topic>DETOXIFICATION</topic><topic>DOSAGE</topic><topic>EA 1814 AGENT</topic><topic>EXCRETION</topic><topic>OXIMES</topic><topic>PYRIDINE ALDOXIME METHOCHLORIDE</topic><topic>PYRIDINE ALDOXIMES</topic><topic>URINE</topic><toplevel>online_resources</toplevel><creatorcontrib>Kondritzer,Albert A</creatorcontrib><creatorcontrib>Zvirblis,Peter</creatorcontrib><creatorcontrib>Goodman,A</creatorcontrib><creatorcontrib>Paplanus,S H</creatorcontrib><creatorcontrib>EDGEWOOD ARSENAL MD</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kondritzer,Albert A</au><au>Zvirblis,Peter</au><au>Goodman,A</au><au>Paplanus,S H</au><aucorp>EDGEWOOD ARSENAL MD</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>BLOOD PLASMA LEVELS AND ELIMINATION OF SALTS OF 2-PAM IN MAN AFTER ORAL ADMINISTRATION</btitle><date>1968-06</date><risdate>1968</risdate><abstract>Adult male volunteers were given, orally, aqueous solutions of each of the chloride, iodide, dihydrogen phosphate, methane sulfonate, and lactate salts of 2-PAM in varying amounts. A measurable amount of oxime was found in blood plasma within about 15 minutes; the concentration rose rapidly, reached a peak at 2 to 3 hours, and then declined at a rate that approximated a first-order process. The rates of absorption into and elimination from plasma of 2-PAMCl and P2S were practically identical. The equation, log Y = 0.79 + 0.54 log X, gives an approximate relationship between peak plasma levels of oxime (Y) and oral doses (X) of the various salts. Accordingly, a 10-fold increase in dosage of the 2-PAM salts increased the peak plasma level of oxime 3.5 fold. The biological half-life in man of the 2-PAM salts given orally, calculated from blood plasma values and urinary excretion rates, was 1.7 hours, with a coefficient of variation of 24%. The average total amount of 2-PAM recovered in the urine was 27%; the standard deviation of individual recoveries was 9%. Considerably less EA 1814 is excreted via the urine; an average of 3% was recovered during 24 hours among three subjects. Clinical changes observed were: (1) iodism symptoms in subjects given 2-PAM and (2) a 20% decrease in both RBC and plasma cholinesterase in subjects given 1 gm/70 kg of EA 1814. All other clinical tests were negative. (Author)</abstract><oa>free_for_read</oa></addata></record> |
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subjects | Biochemistry BIOLOGICAL ABSORPTION BLOOD CHEMISTRY Chemical, Biological and Radiological Warfare CHOLINESTERASE INHIBITORS DETOXIFICATION DOSAGE EA 1814 AGENT EXCRETION OXIMES PYRIDINE ALDOXIME METHOCHLORIDE PYRIDINE ALDOXIMES URINE |
title | BLOOD PLASMA LEVELS AND ELIMINATION OF SALTS OF 2-PAM IN MAN AFTER ORAL ADMINISTRATION |
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