Severity of influenza A(H1N1) illness and emergence of D225G variant, 2013-14 influenza season, Florida, USA

Despite a regional decline in influenza A(H1N1)pdm09 virus infections during 2013-14, cases at a Florida hospital were more severe than those during 2009-10. Examined strains had a hemagglutinin polymorphism associated with enhanced binding to lower respiratory tract receptors. Genetic changes in th...

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Veröffentlicht in:	Emerging infectious diseases 2015-04, Vol.21 (4), p.664-667
Hauptverfasser:	Iovine, Nicole M, Morris, Jr, J Glenn, Fredenburg, Kristianna, Rand, Kenneth, Alnuaimat, Hassan, Lipori, Gloria, Brew, Joseph, Lednicky, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	acute respiratory distress syndrome Adolescent Adult Aged Aged, 80 and over Comorbidity Dispatch Female Florida - epidemiology Genetic Variation H1N1 subtype hemagglutinin History, 21st Century Humans influenza Influenza A Virus, H1N1 Subtype - genetics influenza virus Influenza, Human - epidemiology Influenza, Human - history Influenza, Human - pathology Influenza, Human - virology Lung - pathology Lung - virology Male Middle Aged Mortality pandemic Seasons Young Adult
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Zusammenfassung:	Despite a regional decline in influenza A(H1N1)pdm09 virus infections during 2013-14, cases at a Florida hospital were more severe than those during 2009-10. Examined strains had a hemagglutinin polymorphism associated with enhanced binding to lower respiratory tract receptors. Genetic changes in this virus must be monitored to predict the effect of future pandemic viruses.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2104.141375