Relationship between ocular surface pain and corneal nerve loss in dry eye diabetics: a cross-sectional study in Shenyang, China

BackgroundDiabetes mellitus has been associated with increased dry eye disease (DED) and exacerbates DED pathology.ObjectiveTo investigate the potential relationship between corneal nerve loss and ocular pain among diabetic patients with dry eye (DE).DesignA cross-sectional study.SettingHe Eye Specialist Hospital, Shenyang, China.ParticipantsThis study recruited 124 eyes of 62 diabetic patients diagnosed with DED between August and October 2022.Main outcome measuresBest-corrected visual acuity, intraocular pressure, non-invasive tear breakup time, tear meniscus height, tear film lipid layer, conjunctival hyperaemia (redness score), conjunctivocorneal epithelial staining (CS score), central corneal sensitivity and vitro confocal corneal microscopy was assessed in all subjects. The Ocular Surface Disease Index Questionnaire assessed DE symptoms and ocular pain.ResultsThe study’s final analysis included 26 patients (52 eyes) without ocular pain and 36 patients (72 eyes) with ocular pain. The corneal nerve fibre density (CNFD), corneal nerve branch density (CNBD) and corneal nerve fibre length (CNFL) in patients with ocular pain were significantly lower than those without (p