Melatonin reduces lung injury in type 1 diabetic mice by the modulation of autophagy

In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of autophagy-related genes in the lung tissues following melatonin administration. Data showed his...

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Veröffentlicht in:	BMC cell biology 2024-03, Vol.25 (1), p.7-7, Article 7
Hauptverfasser:	Rezaie, Jafar, Jahanghiri, Mojtaba, Heris, Reza Mosaddeghi, Hassannezhad, Sina, Abdyazdani, Nima, Rahbarghazi, Afshin, Ahmadi, Mahdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Autophagy (Cytology) Complications and side effects Diabetes Diabetes mellitus Fasting Gene expression Genes Glucose Health aspects Histology Hyperglycemia Inflammation Insulin resistance Interleukin 6 Laboratory animals Lung diseases Lung injury Lungs Medical research Medicine, Experimental Melatonin Oxidative stress Pneumonia Prevention Risk factors Statistical analysis Type 1 diabetes Type 2 diabetes
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Zusammenfassung:	In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of autophagy-related genes in the lung tissues following melatonin administration. Data showed histopathological remodeling in lung tissues of the D group coincided with an elevated level of IL-6, Becline-1, LC3, and P62 compared to the control group (p
ISSN:	2661-8850 2661-8850 1471-2121
DOI:	10.1186/s12860-024-00505-9