ASPH Regulates Osteogenic Differentiation and Cellular Senescence of BMSCs

Osteogenesis and senescence of BMSCs play great roles in age-related bone loss. However, the causes of these dysfunctions remain unclear. In this study, we identified a differentially expressed gene in middle-aged and elderly aged groups which were obtained from GSE35955. Subsequent analysis in various databases, such as TCGA, GTEx, and CCLE, revealed that had positive correlations with several osteogenic markers. The depletion of mouse suppressed the capacity of osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs). Notably, the expression of decreased during aging and senescence. The deficiency of accelerated cellular senescence in BMSCs. Conversely, the overexpression of enhanced the capacity of osteogenic differentiation and inhibited cellular senescence. Mechanistically, regulated Wnt signaling mediated by Gsk3β. Taken together, our data established that was potentially involved in the pathogenesis of age-related bone loss through regulating cellular senescence and osteogenic differentiation, which provides some new insights to treat age-related bone loss.