Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury

Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild ma...

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Veröffentlicht in:	Viruses 2021-12, Vol.13 (12), p.2517
Hauptverfasser:	Favre, Guillaume, Mazzetti, Sara, Gengler, Carole, Bertelli, Claire, Schneider, Juliane, Laubscher, Bernard, Capoccia, Romina, Pakniyat, Fatemeh, Ben Jazia, Inès, Eggel-Hort, Béatrice, de Leval, Laurence, Pomar, Léo, Greub, Gilbert, Baud, David, Giannoni, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood platelets Brain damage Brain Injuries - etiology Brain Injuries - pathology Brain injury Case Report Cesarean Section Coronaviruses COVID-19 COVID-19 - complications COVID-19 - physiopathology COVID-19 - virology Disease transmission Extubation Female Fetal Movement fetal movements Fetuses Genomes Humans Infant, Newborn Infant, Premature Infections Infectious Disease Transmission, Vertical Laboratories Leukomalacia, Periventricular - etiology Leukomalacia, Periventricular - pathology Neonates perinatal Placenta Placenta - pathology Placenta - virology placental Pregnancy Pregnancy Complications, Infectious - physiopathology Pregnancy Complications, Infectious - virology Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 - isolation & purification Severe acute respiratory syndrome coronavirus 2 Surfactants Ultrasonic imaging Umbilical cord Ventilators Ventricle Womens health
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Beschreibung
Zusammenfassung:	Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v13122517