Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA)
•More time spent in accelerometry-measured (i.e., ActiGraph) and self-reported moderate-to-vigorous physical activity was associated with significantly higher skeletal muscle energetics (i.e., ATPmax and maxOXPHOS).•More time spent in ActiGraph, but not self-reported daily sedentary behavior, was as...
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Veröffentlicht in: | Journal of sport and health science 2024-09, Vol.13 (5), p.621-630 |
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Zusammenfassung: | •More time spent in accelerometry-measured (i.e., ActiGraph) and self-reported moderate-to-vigorous physical activity was associated with significantly higher skeletal muscle energetics (i.e., ATPmax and maxOXPHOS).•More time spent in ActiGraph, but not self-reported daily sedentary behavior, was associated with lower skeletal muscle energetics.•Higher activPAL step count, but not time spent in sedentary behavior, was associated with higher ATPmax and maxOXPHOS.•Older age was associated with lower muscle energetics for men but not women; adjustment for ActiGraph moderate-to-vigorous physical activity attenuated the age association with ATPmax by 58%, indicating that higher intensity physical activity may offset age-related decline in ATPmax.
Skeletal muscle energetics decline with age, and physical activity (PA) has been shown to offset these declines in older adults. Yet, many studies reporting these effects were based on self-reported PA or structured exercise interventions. Therefore, we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior (SB) with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle energetics.
As part of the Study of Muscle, Mobility and Aging, enrolled older adults (n = 879), 810 (age = 76.4 ± 5.0 years old, mean ± SD; 58% women) had maximal muscle oxidative capacity measured ex vivo via high-resolution respirometry of permeabilized myofibers (maximal oxidative phosphorylation (maxOXPHOS)) and in vivo by 31phosphorus magnetic resonance spectroscopy (maximal adenosine triphosphate (ATPmax)). Accelerometry-measured sedentary behavior, light activity, and moderate-to-vigorous PA (MVPA) were assessed using a wrist-worn ActiGraph GT9X over 7 days. Self-reported sedentary behavior, MVPA, and all PA were assessed with the Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire. Linear regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics, as well as the attenuation of the age/muscle energetics association by MVPA and sedentary behavior. As a sensitivity analysis, we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle energetics.
Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s × mg) higher maxOXPHOS and 0.012 mM |
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ISSN: | 2095-2546 2213-2961 2213-2961 |
DOI: | 10.1016/j.jshs.2024.02.001 |