Relationship of the anxiety-depressive disorder with coronary heart disease, comorbid with metabolic syndrome

Aim. It is expected that combination of anxiety and depressive disorders with components of the metabolic syndrome can summarize their effects that can significantly affect the prognosis of patients with coronary heart disease. Methods and results. In order to establish an interconnections of the anxiety and depressive disorders with components of the metabolic syndrome in patients with coronary artery disease and to assess their impact on the course of the disease 81 patients with a diagnosis of coronary heart disease: angina pectoris II-III functional class were examined. The 1st group consisted of the 35 patients with isolated coronary heart disease, group 2 - 46 patients with coronary heart disease and metabolic syndrome. With the help of clinical and biochemical analysis, daily ECG monitoring, Seattle Angina Questionnaire, SF-36 questionnaire, the Hospital Anxiety and Depression Scale HADS we investigated the severity of anxiety and depression and life quality of the patients , depending on higher overall levels of anxiety and depression on the scale of HADS. Conclusion. It was found that for coronary heart disease concomitant with the metabolic syndrome is associated with higher overall levels of anxiety and depression on the scale of HADS, correlated with components of metabolic syndrome such as abdominal obesity, dyslipidemia and hyperglycemia. The presence of anxiety and depressive disorders in patients with metabolic syndrome, accompanied by more severe clinical course coronary heart disease according to Seattle questionnaire, reduced quality of life for patients, an imbalance of the autonomic nervous system in the direction of increased activity of the sympathetic part.