Synthesis of 8-Aminoquinoline Amides of Ursonic and Oleanonic Acid

8-Aminoquinoline amides of 3-oxo-olean-12-en-28-oic acid and 3-oxo-urs-12-en-28-oic acid were obtained and characterized by 1H, 13C-NMR and single crystal X-ray analysis. The used triterpenoic acids are oxidized forms of naturally occurring oleanolic acid and ursolic acids. Such types of derivatives...

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Veröffentlicht in:	MolBank 2022-05, Vol.2022 (2), p.M1361
Hauptverfasser:	Kroškins, Vladislavs, Lugiņina, Jevgeņija, Mishnev, Anatoly, Turks, Māris
Format:	Artikel
Sprache:	eng
Schlagworte:	8-aminoquinoline amides Amides Aminoquinolines Anticancer properties Biological activity Chloride Chromatography Hydrochloric acid NMR Nuclear magnetic resonance oleanolic acid Single crystals Solvents Transition metals triterpenoids ursolic acid X ray analysis
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Zusammenfassung:	8-Aminoquinoline amides of 3-oxo-olean-12-en-28-oic acid and 3-oxo-urs-12-en-28-oic acid were obtained and characterized by 1H, 13C-NMR and single crystal X-ray analysis. The used triterpenoic acids are oxidized forms of naturally occurring oleanolic acid and ursolic acids. Such types of derivatives are known for their anticancer and antiviral activities. On the other hand, 8-aminoquinoline amides are frequently used for transition metal complexation that is applicable for both C-H activation processes and biological activity studies.
ISSN:	1422-8599 1422-8599
DOI:	10.3390/M1361