The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study

Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer's disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in real-world clinical practice, however, remains to be established. The a...

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Veröffentlicht in:	Alzheimer's research & therapy 2024-10, Vol.16 (1), p.230-11, Article 230
Hauptverfasser:	Vermeiren, Marie R, Somsen, Joost, Luurtsema, Gert, Reesink, Fransje E, Verwey, Nicolaas A, Hempenius, Liesbeth, Tolboom, Nelleke, Biessels, Geert Jan, Biesbroek, J Matthijs, Vernooij, Meike W, Veldhuijzen van Zanten, Sophie E M, Seelaar, Harro, Coomans, Emma M, Teunissen, Charlotte E, Lemstra, Afina W, van Harten, Argonde C, Visser, Leonie N C, van der Flier, Wiesje M, van de Giessen, Elsmarieke, Ossenkoppele, Rik
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - diagnosis Alzheimer Disease - diagnostic imaging Alzheimer's disease Artificial intelligence Biomarkers - cerebrospinal fluid Clinical Medicine Cognitive Dysfunction - diagnosis Cognitive Dysfunction - diagnostic imaging Cohort Studies Dementia Diagnosis Female Humans Klinisk medicin Longitudinal Studies Male Medical and Health Sciences Medicin och hälsovetenskap Methods Middle Aged Netherlands Neurologi Neurology PET imaging Positron emission tomography Positron-Emission Tomography - methods Prospective Studies Tau Tau proteins tau Proteins - cerebrospinal fluid tau Proteins - metabolism
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Zusammenfassung:	Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer's disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in real-world clinical practice, however, remains to be established. The aim of the TAP-TAU study is therefore to investigate the impact of tau-PET in clinical practice. TAP-TAU is a prospective, longitudinal multi-center study in 300 patients (≥ 50 years old) with mild cognitive impairment or mild dementia across five Dutch memory clinics. Patients are eligible if diagnostic certainty is
ISSN:	1758-9193 1758-9193
DOI:	10.1186/s13195-024-01588-4