Efficacy of Sublingual Immunotherapy with Dermatophagoides Pteronyssinus: A Real-life Study

Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficac...

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Veröffentlicht in:	Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2016-04, Vol.15 (2), p.112
Hauptverfasser:	Vesna, Tomic-Spiric, Denisa, Dizdarevic, Slavenka, Jankovic, Lidija, Burazer, Aleksandra, Barac, Jasna, Bolpacic, Vojislav, Djuric, Aleksandra, Peric-Popadic, Aleksandra, Aleksic, Mirjana, Bogic
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Allergic rhinitis Allergies Animals Asthma Asthma - immunology Asthma - therapy Clinical trials Complex Mixtures - administration & dosage Complex Mixtures - chemistry Complex Mixtures - immunology Dermatophagoides pteronyssinus Dermatophagoides pteronyssinus - chemistry Dermatophagoides pteronyssinus - immunology Drug dosages Drug therapy Efficacy Female Hay fever Humans Immunoglobulin G - immunology Immunology Immunotherapy Male Middle Aged Molecular weight Oral administration Patients Proteins Rhinitis Rhinitis, Allergic - immunology Rhinitis, Allergic - therapy Skin tests Studies Sublingual Immunotherapy Sublingual Immunotherapy - methods Virology
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Zusammenfassung:	Sublingual allergen immunotherapy (SLIT) is considered to be safer and more convenient than subcutaneus immunotherapy. SLIT trials with house dust mites involving patients with allergic rhinitis (AR) and asthma reported discordant results. The aim of the study was to investigate the clinical efficacy and safety of SLIT with Dermatophagoides pteronyssinus (D.pt) extract produced in Serbia and patient's satisfaction through open-label trial. Adult patients with allergic rhinitis were randomized into two groups: one received drugs and SLIT, while other received only drugs. Symptom score (SS), medication score (MS) and cumulative score (CS), skin prick tests (SPT) and serum level of D. pt specific IgE were assessed. One year after, the patients were re-evaluated. In total, 61 patients were enrolled in the study, but 52 of them were analyzed at the end of the year. CS (29.3%, p
ISSN:	1735-1502 1735-5249