High rates of antimicrobial drug resistance gene acquisition after international travel, The Netherlands

High rates of antimicrobial drug resistance gene acquisition after international travel, The Netherlands

We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum β-lactamase encoding gene blaCTX-M, documenting a rise in prevalence fro...

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Veröffentlicht in:Emerging infectious diseases 2014-04, Vol.20 (4), p.649-657
Hauptverfasser: von Wintersdorff, Christian J H, Penders, John, Stobberingh, Ellen E, Oude Lashof, Astrid M L, Hoebe, Christian J P A, Savelkoul, Paul H M, Wolffs, Petra F G
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Bacterial Proteins - genetics
beta-Lactamases - genetics
CTX-M
Drug resistance
Drug Resistance, Multiple, Bacterial - genetics
ESBL
Female
Gastrointestinal Tract - microbiology
Genes, Bacterial - genetics
Genetic aspects
Health aspects
Humans
Male
Metagenomics - methods
Middle Aged
Netherlands
Prevalence
qnrB
qnrS
quinolone
Quinolones - pharmacology
resistance genes
Statistics
Travel
Young Adult
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Beschreibung
Zusammenfassung:We investigated the effect of international travel on the gut resistome of 122 healthy travelers from the Netherlands by using a targeted metagenomic approach. Our results confirm high acquisition rates of the extended-spectrum β-lactamase encoding gene blaCTX-M, documenting a rise in prevalence from 9.0% before travel to 33.6% after travel (p
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2004.131718