Nimesulide Based Novel Glycolamide Esters: Their Design, Synthesis, and Pharmacological Evaluation

Nimesulide Based Novel Glycolamide Esters: Their Design, Synthesis, and Pharmacological Evaluation

The nimesulide based novel glycolamide esters were designed and synthesized for the first time via a three-step method starting from nimesulide. Structures of the synthesized compounds were confirmed by spectroscopic analysis. All the synthesized compounds were examined for their cytotoxic effects i...

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Veröffentlicht in:Journal of chemistry 2013-01, Vol.2013 (1)
Hauptverfasser: Kankanala, Kavitha, Reddy, Vangala Ranga, Devi, Yumnam Priyadarshini, Mangamoori, Lakshmi Narasu, Mukkanti, Khagga, Pal, Sarbani
Format: Artikel
Sprache:eng
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Zusammenfassung:The nimesulide based novel glycolamide esters were designed and synthesized for the first time via a three-step method starting from nimesulide. Structures of the synthesized compounds were confirmed by spectroscopic analysis. All the synthesized compounds were examined for their cytotoxic effects in vitro, some of which showed significant cytotoxic activities against HCT-15 human colon cancer cell line.
ISSN:2090-9063
2090-9071
DOI:10.1155/2013/816769