Biodistribution studies of bee venom and spider toxin using radiotracers

Biodistribution studies of bee venom and spider toxin using radiotracers

The use of radiotracers allows the understanding of the bioavailability process, biodistribution, and kinetics of any molecule labelled with an isotope, which does not alter the molecule's biological properties. In this work, technetium-99m and iodine-125 were chosen as radiotracers for biodist...

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Veröffentlicht in:The journal of venomous animals and toxins including tropical diseases 2005-03, Vol.11 (1), p.39-50
Hauptverfasser: Yonamine, C. M.(Instituto de Pesquisas Energéticas e Nucleares Centro de Biologia Molecular), Costa, H.(Instituto de Pesquisas Energéticas e Nucleares Centro de Biologia Molecular), Silva, J. A. A.(Instituto de Pesquisas Energéticas e Nucleares Centro de Biologia Molecular), Muramoto, E.(Instituto de Pesquisas Energéticas e Nucleares Centro de Biologia Molecular), Rogero, J. R.(Instituto de Pesquisas Energéticas e Nucleares Centro de Biologia Molecular), Troncone, L. R. P.(Instituto Butantan Laboratório de Farmacologia), Camillo, M. A. P.(Instituto de Pesquisas Energéticas e Nucleares Centro de Biologia Molecular)
Format: Artikel
Sprache:eng
Schlagworte:
Apis mellifera
Araneae
biodistribution
Phoneutria nigriventer
radiotracer
TOXICOLOGY
toxin
TROPICAL MEDICINE
venom
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Zusammenfassung:The use of radiotracers allows the understanding of the bioavailability process, biodistribution, and kinetics of any molecule labelled with an isotope, which does not alter the molecule's biological properties. In this work, technetium-99m and iodine-125 were chosen as radiotracers for biodistribution studies in mice using bee (Apis mellifera) venom and a toxin (PnTX2-6) from the Brazilian "armed" spider (Phoneutria nigriventer) venom. Incorporated radioactivity was measured in the blood, brain, heart, lung, liver, kidney, adrenal gland, spleen, stomach, testicle, intestine, muscle, and thyroid gland. Results provided the blood kinetic parameter, and different organs distribution rates.
ISSN:1678-9199
1678-9199
DOI:10.1590/S1678-91992005000100006