Synthesis and Biological Evaluation of Thiazole-Based Derivatives with Potential against Breast Cancer and Antimicrobial Agents

Investigating novel, biologically-active coordination compounds that may be useful in the design of breast anticancer, antifungal, and antimicrobial agents is still the main challenge for chemists. In order to get closer to solving this problem, three new copper coordination compounds containing thi...

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Veröffentlicht in:International journal of molecular sciences 2022-09, Vol.23 (17), p.9844
Hauptverfasser: Pivovarova, Ekaterina, Climova, Alina, Świątkowski, Marcin, Staszewski, Marek, Walczyński, Krzysztof, Dzięgielewski, Marek, Bauer, Marta, Kamysz, Wojciech, Krześlak, Anna, Jóźwiak, Paweł, Czylkowska, Agnieszka
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Sprache:eng
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Zusammenfassung:Investigating novel, biologically-active coordination compounds that may be useful in the design of breast anticancer, antifungal, and antimicrobial agents is still the main challenge for chemists. In order to get closer to solving this problem, three new copper coordination compounds containing thiazole-based derivatives were synthesized. The structures of the synthesized compounds and their physicochemical characterization were evaluated based on elemental analysis, 1H and l3C nuclear magnetic resonance (NMR), flame atomic absorption spectroscopy (F-AAS), single-crystal X-ray diffraction, thermogravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FTIR). The pharmacokinetics were studied using SwissADME. The results obtained from the computational studies supported the results obtained from the MTT analysis, and the antimicrobial activity was expressed as the minimum inhibitory concentration (MIC).
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23179844