Multi-omics analyses of gut microbiota via 16S rRNA gene sequencing, LC-MS/MS and diffusion tension imaging reveal aberrant microbiota-gut-brain axis in very low or extremely low birth weight infants with white matter injury

The goal of this study was to comprehensively investigate the characteristics of gut microbiota dysbiosis and metabolites levels in very low or extremely low birth weight (VLBW/ELBW) infants with white matter injury (WMI). In this prospective cohort study, preterm infants with gestational age

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Bibliographische Detailangaben
Veröffentlicht in:	BMC microbiology 2023-12, Vol.23 (1), p.387-17, Article 387
Hauptverfasser:	Liu, Ling, Xiang, Min, Cai, Xiangsheng, Wu, Benqing, Chen, Chaohong, Cai, Nali, Ao, Dang
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3-Butadiene Acinetobacter Bile acids Biomarkers Biosynthesis Birth weight Birth weight, Low Brain Brain damage Brain-Gut Axis Butadiene Cerebral palsy Cholic acid Chromatography, Liquid Congenital diseases Corpus callosum Diagnosis Diagnostic imaging Diffusion tension imaging Discriminant analysis DNA sequencing Down-regulation Dysbacteriosis Dysbiosis Feces g_Staphylococcus Gastrointestinal Microbiome - genetics Gene sequencing Genes Genes, rRNA Genomes Gestational age Gut microbiota Health aspects Humans Infant Infant, Extremely Low Birth Weight Infant, Newborn Infant, Premature Infants Infants (Premature) Injuries Intestinal microflora Liquid chromatography Low birth weight Magnetic resonance imaging Mass spectrometry Medical examination Medical imaging Medical imaging equipment Metabolic pathways Metabolism Metabolites Microbiota Microbiota (Symbiotic organisms) Microbiota-gut-brain axis Microorganisms Multiomics Myelination Neuroimaging Newborn babies Pediatric research Premature babies Prospective Studies Refuse disposal industry Ribonucleic acid RNA RNA sequencing RNA, Ribosomal, 16S - analysis RNA, Ribosomal, 16S - genetics rRNA 16S Staphylococcus Substantia alba Tandem Mass Spectrometry Taxonomy Traumatic brain injury White Matter - chemistry White Matter - diagnostic imaging White matter injury
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Zusammenfassung:	The goal of this study was to comprehensively investigate the characteristics of gut microbiota dysbiosis and metabolites levels in very low or extremely low birth weight (VLBW/ELBW) infants with white matter injury (WMI). In this prospective cohort study, preterm infants with gestational age
ISSN:	1471-2180 1471-2180
DOI:	10.1186/s12866-023-03103-5