Broadcasting of Cortical Activity to the Olfactory Bulb

Odor representations are initially formed in the olfactory bulb, which contains a topographic glomerular map of odor molecular features. The bulb transmits sensory information directly to piriform cortex, where it is encoded by distributed ensembles of pyramidal cells without spatial order. Intriguingly, piriform cortex pyramidal cells project back to the bulb, but the information contained in this feedback projection is unknown. Here, we use imaging in awake mice to directly monitor activity in the presynaptic boutons of cortical feedback fibers. We show that the cortex provides the bulb with a rich array of information for any individual odor and that cortical feedback is dependent on brain state. In contrast to the stereotyped, spatial arrangement of olfactory bulb glomeruli, cortical inputs tuned to different odors commingle and indiscriminately target individual glomerular channels. Thus, the cortex modulates early odor representations by broadcasting sensory information diffusely onto spatially ordered bulbar circuits. [Display omitted] •Olfactory cortical feedback activity is examined via bouton GCaMP6 imaging in awake mice•Feedback projections show diverse odor-evoked response properties•Feedback activity is regulated by brain state•Corticobulbar feedback is diffuse and lacks discernible topographic organization Boyd et al. show that olfactory cortical feedback projections have brain-state-dependent activity and diverse odor-evoked responses and lack functional topographic organization within the olfactory bulb. This suggests that corticobulbar feedback maintains the distributed organization of the piriform cortex and broadcasts odor information diffusely across bulbar circuits.