Protective Effect of Aloe vera Extract against Bisphenol A Induced Testicular Toxicity in Wistar Rats

Bisphenol A (BPA), an endocrine-disrupting chemical, has been considered as a possible risk factor for fertility because it induces testicular toxicity. Thus, we sought to analyze the effect of Aloe vera as plant with antioxidant properties on tissues and oxidative stress parameters in male rats. In this experimental study, 50 adult male Wistar rats (200 ± 20 g) have been used in this 56 day study. Animals were completely randomized and divided into five groups: A (control), A (vehicle control), A (Aloe vera gel 300 mg/kg), B (BPA 20 μg/kg bw) and B (Aloe vera gel+ BPA). At the end of the study, the rats were anesthetized and 2 ml blood samples were obtained for evaluation of oxidative stress markers. Also, both testes were collected for histological examinations. BPA significantly decreased (P