The role of hematopoietic stem cell niche in prostate cancer bone metastasis

Abstract Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the dev...

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Veröffentlicht in:	Journal of bone oncology 2016-09, Vol.5 (3), p.117-120
Hauptverfasser:	Decker, A.M, Jung, Y, Cackowski, F, Taichman, R.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Hematology, Oncology and Palliative Medicine Research Paper
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Abstract Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development of novel prostate cancer therapies. This paper reviews aspects of the HSC niche that lead to prostate cancer cell homing and dormancy in the bone marrow. This review also discusses the role of DTCs in the niche environment and discusses the role of erythropoietin in targeting DTCs within the HSC niche.
ISSN:	2212-1374 2212-1366 2212-1374
DOI:	10.1016/j.jbo.2016.02.005