Accelerated biological aging in COVID-19 patients

Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. In this study, DNA methylation of the blood samples from 232 healt...

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Veröffentlicht in:	Nature communications 2022-04, Vol.13 (1), p.2135-2135, Article 2135
Hauptverfasser:	Cao, Xue, Li, Wenjuan, Wang, Ting, Ran, Dongzhi, Davalos, Veronica, Planas-Serra, Laura, Pujol, Aurora, Esteller, Manel, Wang, Xiaolin, Yu, Huichuan
Format:	Artikel
Sprache:	eng
Schlagworte:	45/22 45/61 631/208/176/1988 631/443/7 692/699/255/2514 Accumulation Age Aging Aging - genetics Blood Clocks Coronaviruses COVID-19 COVID-19 - complications COVID-19 - genetics Deoxyribonucleic acid DNA DNA fingerprinting DNA Methylation Epigenesis, Genetic Epigenetics Humanities and Social Sciences Humans Infections multidisciplinary Risk analysis Risk factors SARS-CoV-2 Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Telomeres Viral diseases
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Zusammenfassung:	Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. In this study, DNA methylation of the blood samples from 232 healthy individuals and 413 COVID-19 patients is profiled using EPIC methylation array. Epigenetic ages of each individual are determined by applying epigenetic clocks and telomere length estimator to the methylation profile of the individual. Epigenetic age acceleration is calculated and compared between groups. We observe strong correlations between the epigenetic clocks and individual’s chronological age ( r > 0.8, p
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-022-29801-8