Timing and cell specificity of senescence drives postnatal lung development and injury

Timing and cell specificity of senescence drives postnatal lung development and injury

Senescence causes age-related diseases and stress-related injury. Paradoxically, it is also essential for organismal development. Whether senescence contributes to lung development or injury in early life remains unclear. Here, we show that lung senescence occurred at birth and decreased throughout...

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Veröffentlicht in:Nature communications 2023-01, Vol.14 (1), p.273-273, Article 273
Hauptverfasser: Yao, Hongwei, Wallace, Joselynn, Peterson, Abigail L., Scaffa, Alejandro, Rizal, Salu, Hegarty, Katy, Maeda, Hajime, Chang, Jason L., Oulhen, Nathalie, Kreiling, Jill A., Huntington, Kelsey E., De Paepe, Monique E., Barbosa, Guilherme, Dennery, Phyllis A.
Format: Artikel
Sprache:eng
Schlagworte:
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Age
Age related diseases
Alveoli
Animals
Animals, Newborn
Humanities and Social Sciences
Hyperoxia
Hyperoxia - metabolism
Immune system
Injuries
Lung - metabolism
Lung Injury - metabolism
Lungs
Mesenchyme
Mice
multidisciplinary
Neonates
Nitric oxide
Ontogeny
Pulmonary Alveoli - metabolism
Saccule
Science
Science (multidisciplinary)
Senescence
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Beschreibung
Zusammenfassung:Senescence causes age-related diseases and stress-related injury. Paradoxically, it is also essential for organismal development. Whether senescence contributes to lung development or injury in early life remains unclear. Here, we show that lung senescence occurred at birth and decreased throughout the saccular stage in mice. Reducing senescent cells at this stage disrupted lung development. In mice (
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-35985-4