A chromosome-level genome assembly of Cydia pomonella provides insights into chemical ecology and insecticide resistance
The codling moth Cydia pomonella , a major invasive pest of pome fruit, has spread around the globe in the last half century. We generated a chromosome-level scaffold assembly including the Z chromosome and a portion of the W chromosome. This assembly reveals the duplication of an olfactory receptor...
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Veröffentlicht in: | Nature communications 2019-09, Vol.10 (1), p.4237-14, Article 4237 |
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Sprache: | eng |
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Zusammenfassung: | The codling moth
Cydia pomonella
, a major invasive pest of pome fruit, has spread around the globe in the last half century. We generated a chromosome-level scaffold assembly including the Z chromosome and a portion of the W chromosome. This assembly reveals the duplication of an olfactory receptor gene (
OR3
), which we demonstrate enhances the ability of
C. pomonella
to exploit kairomones and pheromones in locating both host plants and mates. Genome-wide association studies contrasting insecticide-resistant and susceptible strains identify hundreds of single nucleotide polymorphisms (SNPs) potentially associated with insecticide resistance, including three SNPs found in the promoter of
CYP6B2
. RNAi knockdown of
CYP6B2
increases
C. pomonella
sensitivity to two insecticides, deltamethrin and azinphos methyl. The high-quality genome assembly of
C. pomonella
informs the genetic basis of its invasiveness, suggesting the codling moth has distinctive capabilities and adaptive potential that may explain its worldwide expansion.
The codling moth,
Cydia pomonella
, is one of the major pests of pome fruit (apples and pears) and walnuts. Here, the authors sequence and analyze its genome, providing insights on olfactory and detoxification processes that may underlie its worldwide expansion. |
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ISSN: | 2041-1723 2041-1723 |
DOI: | 10.1038/s41467-019-12175-9 |