Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens and the liver. This study investigated the gastroprotective effects of C. paniculatum leaf extract and its fractions on absolute...

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Veröffentlicht in:Future Journal of Pharmaceutical Sciences 2022-12, Vol.8 (1), p.1-11, Article 54
Hauptverfasser: Emmanuel, Peter Ikechukwu, Sandra, Ugwu Chikamso, Marytheresa, Onwuka Akachukwu, Nwakaego, Mbaoji Florence, Nneoma, Ofokansi Martha, Azubuike, Onyeto Collins, Uzor, Philip F.
Format: Artikel
Sprache:eng
Schlagworte:
Absolute ethanol
Acetaldehyde
Acids
Alcohol
Alcohol, Denatured
Antacids
Catalase
Combretum paniculatum
Drug dosages
Ethanol
Ethylenediaminetetraacetic acid
Gastric ulcer
Gastrointestinal diseases
Gastroprotection
Laboratories
Liver
Medicine
Medicine & Public Health
Medicine, Botanic
Medicine, Herbal
Mortality
Omeprazole
Organic compounds
Oxidative stress
Pharmaceutical sciences
Pharmaceuticals
Phytochemicals
Solvents
Stomach
Surface active agents
Toxicity
Ulcers
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Zusammenfassung:Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens and the liver. This study investigated the gastroprotective effects of C. paniculatum leaf extract and its fractions on absolute ethanol-induced gastric ulcers in rats and explored their effects on endogenous antioxidant (SOD, MDA, GSH, and Catalase) levels. Butanol, n-hexane, and ethyl acetate extracts (100 and 200 mg/kg), omeprazole (20 mg/kg), and control (3% Tween 80) were administered orally. Results The methanolic extract and fractions of C. paniculatum exhibited varying degrees of ulcer protection. MECP exhibited significant ( P  
ISSN:2314-7253
2314-7245
2314-7253
DOI:10.1186/s43094-022-00442-4