A population-based longitudinal study on glycated hemoglobin levels and new-onset chronic kidney disease among non-diabetic Japanese adults

Chronic kidney disease (CKD) is a major global public health problem. Recent studies reported that diabetes and prediabetes are risk factors for developing CKD; however, the exact glycated hemoglobin (HbA1c) cut-off value for prediabetes remains controversial. In this study, we aimed to examine the...

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Veröffentlicht in:	Scientific reports 2023-08, Vol.13 (1), p.13770-13, Article 13770
Hauptverfasser:	Okawa, Yukari, Suzuki, Etsuji, Mitsuhashi, Toshiharu, Tsuda, Toshihide, Yorifuji, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	692/700/478 692/700/478/174 692/700/478/2772 Adult Body weight Confidence intervals Diabetes Diabetes mellitus East Asian People Glomerular filtration rate Glycated Hemoglobin Hemoglobin Humanities and Social Sciences Humans Kidney diseases Kidneys Longitudinal Studies Male multidisciplinary Overweight Population studies Population-based studies Prediabetic State - epidemiology Public health Renal Insufficiency, Chronic - epidemiology Risk factors Science Science (multidisciplinary)
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Zusammenfassung:	Chronic kidney disease (CKD) is a major global public health problem. Recent studies reported that diabetes and prediabetes are risk factors for developing CKD; however, the exact glycated hemoglobin (HbA1c) cut-off value for prediabetes remains controversial. In this study, we aimed to examine the relationship between HbA1c levels and subsequent CKD development in greater detail than previous studies. Longitudinal data of annual checkups of 7176 Japanese non-diabetic people (male: 40.4%) from 1998 to 2022 was analyzed. HbA1c values were categorized into
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-40300-8