GUT MICROBIOTA AND ITS RELATIONS WITH CARDIOVASCULAR RISK FACTORS IN ALMOST HEALTHY INHABITANTS OF MOSCOW AND MOSCOW REGION

Aim. To investigate on the relation of microbiota content and cardiovascular risk factors among persons with no clinical signs of cardiovascular diseases.Material and methods. In the study, 92 Moscow and Moscow Region inhabitants included, men and women at age 25-76 y.o., with no clinical signs of chronic non-infectious diseases, not taking any medications, but with probable existence of cardiovascular risk factors. All participants underwent prescreening investigation that included physical examination, clinical and biochemical blood collection, electrocardiography, thread-mill test, risk factors assessment, and sequencing of the variable loci V3-V4 of the gene 16S of rRNA of gut microbiota.Results. During the study, it was revealed that in the studied cohort there were more opportunistic bacteria in the donors having risk factors: Serratia — in obese and glucose metabolism disorder, Prevotella — in obese, disordered glucose metabolism and raised systolic pressure, Blautia — glucose metabolism disorder and raised systolic pressure. Amylolytic bacteria Oscillosipa were less common in obese.Conclusion. The dysbalance of gut microbiota with riased level of opportunistic bacteria that potentially initiate systemic non-specific inflammation, is associated with the existence of cardiovascular risk factors.