Cerebrospinal fluid and neural stem cell niche control

According to Lim and Alvarez-Buylla (2014), NSCs have their origin in modified astrocites (activated B cells in [Figure 1]); these generate the transit-amplifying cells (C cells in [Figure 1]), which finally become migrating neuroblasts (A cells in [Figure 1]). [...]they are able to self-renew so as to maintain a constant cell population or, in some cases, to expand it; this involves a mitotic ability specific for these cells in the central nervous system. [...]the adult brain neural stem cells (NSCs originating in the radial glia) located in the SVZ and SGZ of the DG, both close to the lateral ventricle, seem to maintain contact with the ventricular cavity. [...]in the SVZ niche the existence has been shown of a single cytoplasmic prolongation for each undifferentiated precursor, which comes into contact with the ventricular cavity through the ependymal cell layer and extends single cilia inside the cavity, which is considered an aerial to recover signals from the CSF.