Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy

Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy

The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer st...

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Veröffentlicht in:Biomolecules (Basel, Switzerland) Switzerland), 2022-05, Vol.12 (5), p.702
Hauptverfasser: Lo Iacono, Melania, Modica, Chiara, Porcelli, Gaetana, Brancato, Ornella Roberta, Muratore, Giampaolo, Bianca, Paola, Gaggianesi, Miriam, Turdo, Alice, Veschi, Veronica, Todaro, Matilde, Di Franco, Simone, Stassi, Giorgio
Format: Artikel
Sprache:eng
Schlagworte:
Adipocytes
Adipocytes - metabolism
adipokines
Adipose tissue
Adipose Tissue - metabolism
Body fat
Breast cancer
Cancer
cancer stem cells
Chronic illnesses
Cytokines
exosomes
Genotype & phenotype
Growth factors
Hormones
Humans
Inflammation
Lipids
Medical innovations
Medical prognosis
Metabolism
Metabolites
Mutation
Neoplasms - metabolism
Neoplastic Stem Cells - metabolism
Obesity
Review
Stem cells
Stromal cells
target therapy
Therapeutic targets
Tumor Microenvironment
Tumor necrosis factor-TNF
Tumors
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Beschreibung
Zusammenfassung:The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirectional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12050702