Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions

Copper-Catalyzed Diboron-Mediated cis-Semi-Hydrogenation of Alkynes under Facile Conditions

Cis-alkenes are ubiquitous in biological molecules, which makes it greatly significant to develop efficient methods toward construction of cis-olefins. Herein, we reported a facile semi-hydrogenation of alkynes to cis-alkenes in an efficient way with cuprous bromide/tributylphosphine as the catalyst...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2022-10, Vol.27 (21), p.7213
Hauptverfasser: Zeng, Yuxi, Zhang, Honggang, Ma, Daofan, Wang, Guangwei
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Alkynes
bis(pinacolato)diboron
Catalysts
Caustic soda
cis-selective semi-hydrogenation of alkynes
copper catalysis
Experiments
Hydrogen
Hydrogenation
Ligands
Reagents
Stereoselectivity
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Beschreibung
Zusammenfassung:Cis-alkenes are ubiquitous in biological molecules, which makes it greatly significant to develop efficient methods toward construction of cis-olefins. Herein, we reported a facile semi-hydrogenation of alkynes to cis-alkenes in an efficient way with cuprous bromide/tributylphosphine as the catalyst and bis(pinacolato)diboron/methanol as the hydrogen donor. The method features convenient and facile reaction conditions, wide substrate scope, high yields, and high stereoselectivity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27217213