The role of R-loops in transcription-associated DNA double-strand break repair

The role of R-loops in transcription-associated DNA double-strand break repair

The roles of RNA in the DNA damage response are emerging. We highlight findings from our recent study demonstrating the mechanism for transcription-associated homologous recombination repair (TA-HRR) of DNA double-strand breaks and the critical role of R-loops in TA-HRR.

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Veröffentlicht in:Molecular & cellular oncology 2019-01, Vol.6 (1), p.1542244-1542244
Hauptverfasser: Kato, Reona, Miyagawa, Kiyoshi, Yasuhara, Takaaki
Format: Artikel
Sprache:eng
Schlagworte:
Author’s Views
DNA double-strand break
DNA-RNA hybrid
R-loop
RAD52
transcription-associated homologous recombination repair
XPG
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Zusammenfassung:The roles of RNA in the DNA damage response are emerging. We highlight findings from our recent study demonstrating the mechanism for transcription-associated homologous recombination repair (TA-HRR) of DNA double-strand breaks and the critical role of R-loops in TA-HRR.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2018.1542244