Clinical Effect of Vitamin D on Children with Global Developmental Delay

Background Except for global developmental delay (GDD) caused by certain metabolic diseases with clear causes, rehabilitation treatment is the main treatment for GDD. Vitamin D plays an important neuroprotective role in regulating the development and differentiation of nerve cells by affecting neurotrophic factors; however, there is no study on the clinical effect of vitamin D supplementation on children with GDD. Objective To explore the clinical effects of vitamin D supplementation at different doses on the rehabilitation of children with GDD. Methods A total of 110 children with GDD who were hospitalized for the first time in the Department of Rehabilitation of the Third Affiliated Hospital of Zhengzhou University from September 2020 to June 2022 were selected as the study subjects and divided into the conventional group (n=38), 400 U group (n=37) and 1 200 U group (n=35) using a randomized block grouping method. The conventional group only received conventional rehabilitation; 400 U/d of vitamin D was giv