Oat globulin peptides regulate antidiabetic drug targets and glucose transporters in Caco-2 cells

[Display omitted] •Twenty-two peptides were identified from the tryptic hydrolysates of oat globulin.•Oat peptides competitively suppressed DPP4 and α-glucosidase in Caco-2 cells.•Oat peptides downregulated the protein expressions of DPP4.•Oat peptides elevated α-glucosidase, GLUT2 and GLUT5 protein expressions. This study clarified the effects of well-characterized oat globulin peptides on antidiabetic drug targets (dipeptidyl peptidase IV [DPP4], α-glucosidase, glucose transporters 2 and 5 [GLUT2, GLUT5]) in Caco-2 cells. Twenty-two peptides with over 8 residues were identified from the tryptic hydrolysates (OGb, MM