Advances in the Asymmetric Synthesis of BINOL Derivatives

BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.28 (1), p.12
Hauptverfasser:	da Silva, Everton Machado, Vidal, Hérika Danielle Almeida, Januário, Marcelo Augusto Pereira, Corrêa, Arlene Gonçalves
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric synthesis Asymmetry BINOL Catalysis Catalysts Chemical bonds Chemical research Chirality chirality transfer Coordination compounds kinetic resolution Ligands Metal complexes metal-mediated enantioselective coupling Natural products Organic compounds organocatalysis Oxidation Review Synthesis
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Beschreibung
Zusammenfassung:	BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral BINOLs, highlighting the use of metal complexes and organocatalysts as well as kinetic resolution. Further derivatizations of BINOLs are also discussed.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules28010012