The Synergistic Combination of Curcumin and Polydatin Improves Temozolomide Efficacy on Glioblastoma Cells

Glioblastoma (GBL) is one of the more malignant primary brain tumors; it is currently treated by a multimodality strategy including surgery, and radio- and chemotherapy, mainly consisting of temozolomide (TMZ)-based chemotherapy. Tumor relapse often occurs due to the establishment of TMZ resistance,...

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Veröffentlicht in:	International journal of molecular sciences 2024-10, Vol.25 (19), p.10572
Hauptverfasser:	Serafino, Annalucia, Krasnowska, Ewa Krystyna, Romanò, Sabrina, De Gregorio, Alex, Colone, Marisa, Dupuis, Maria Luisa, Bonucci, Massimo, Ravagnan, Giampietro, Stringaro, Annarita, Fuggetta, Maria Pia
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain tumors Cancer Cancer therapies Cell Cycle - drug effects Cell differentiation Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects chemoresistance Chemotherapy curcumin Curcumin - pharmacology Cytotoxicity Development and progression DNA methylation DNA repair Drug dosages Drug Synergism Functional foods Functional foods & nutraceuticals glioblastoma Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma multiforme Glioma Glucosides - pharmacology Humans Medical prognosis Morphology Muscle proteins polydatin Resveratrol Stilbenes - pharmacology Temozolomide Temozolomide - pharmacology
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Zusammenfassung:	Glioblastoma (GBL) is one of the more malignant primary brain tumors; it is currently treated by a multimodality strategy including surgery, and radio- and chemotherapy, mainly consisting of temozolomide (TMZ)-based chemotherapy. Tumor relapse often occurs due to the establishment of TMZ resistance, with a patient median survival time of
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms251910572