Efficacy and safety of patients with chronic kidney disease undergoing left atrial appendage closure for atrial fibrillation

The relative safety and efficacy of left atrial appendage closure (LAAC) for atrial fibrillation (AF) in patients with chronic kidney disease (CKD) have not been well defined. To evaluate the results in this cohort, we conducted a systematic review and meta-analysis of observational studies. We sear...

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Veröffentlicht in:	PloS one 2023-10, Vol.18 (10), p.e0287928
Hauptverfasser:	Liu, Chaofan, Han, Shaojie, Cui, Kaijun, Wang, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury Atrial Appendage - surgery Atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - epidemiology Atrial Fibrillation - surgery Biology and Life Sciences Care and treatment Chronic kidney failure Complications and side effects Diagnosis Hemorrhage - complications Humans Kidney Failure, Chronic - complications Medicine and Health Sciences Observational Studies as Topic Overview Pericardial Effusion - complications Physical Sciences Renal Insufficiency, Chronic - complications Research and Analysis Methods Stroke - complications Treatment Outcome
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Zusammenfassung:	The relative safety and efficacy of left atrial appendage closure (LAAC) for atrial fibrillation (AF) in patients with chronic kidney disease (CKD) have not been well defined. To evaluate the results in this cohort, we conducted a systematic review and meta-analysis of observational studies. We searched the PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to January 2023 for all relevant studies. Our inclusion criteria were met by twelve observational studies that included 61324 patients altogether. Compared with no CKD group, in-hospital mortality (OR: 2.84, 95% CI: 2.12-3.81, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0287928