Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat

Subtle Cardiovascular Dysfunction in the Unilateral 6-Hydroxydopamine-Lesioned Rat

The present study evaluated whether the unilateral 6-hydroxydopamine (6-OHDA) model of Parkinson's disease produces autonomic deficits. Autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate variability (HRV), diurnal rhythms of heart...

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Veröffentlicht in:Parkinson's disease 2010-01, Vol.2010 (2010), p.1-10
Hauptverfasser: Einstein, R., Allbutt, H. N., Matthews, S., Billing, R., Slack, K., Henderson, J. M.
Format: Artikel
Sprache:eng
Schlagworte:
Cardiovascular diseases
Complications and side effects
Diagnosis
Dopamine
Heart beat
Parkinson's disease
Physiological aspects
Risk factors
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Zusammenfassung:The present study evaluated whether the unilateral 6-hydroxydopamine (6-OHDA) model of Parkinson's disease produces autonomic deficits. Autonomic parameters were assessed by implanting a small radiofrequency telemetry device which measured heart rate variability (HRV), diurnal rhythms of heart rate (HR), core body temperature (cBT) and locomotor activity (LA). Rats then received 6-OHDA lesion or sham surgery. 6-OHDA lesioned rats exhibited head and body axis biases, defective sensorimotor function (“disengage” test), and prominent apomorphine rotation (all P
ISSN:2090-8083
2042-0080
2042-0080
DOI:10.4061/2010/427810