Mitochondrial DNA D-loop sequencing reveals obesity variants in an Arab population

Mitochondrial DNA D-loop sequencing reveals obesity variants in an Arab population

The association of mitochondrial DNA (mtDNA) variations with obesity has been investigated in diverse populations across the world. However, such obesity-associated mtDNA examinations are rarely conducted in Arab populations. We re-sequenced mtDNA displacement loop (D-loop) region of 395 Arab indivi...

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Veröffentlicht in:Application of clinical genetics 2019-05, Vol.12, p.63-70
Hauptverfasser: Eaaswarkhanth, Muthukrishnan, Melhem, Motasem, Sharma, Prem, Nizam, Rasheeba, Al Madhoun, Ashraf, Chaubey, Gyaneshwer, Alsmadi, Osama, AlOzairi, Ebaa, Al-Mulla, Fahd
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Body mass index
D-Loop
DNA
Genomes
haplogroup
haplotype
Mitochondrial DNA
Obesity
Original Research
SNVs
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Beschreibung
Zusammenfassung:The association of mitochondrial DNA (mtDNA) variations with obesity has been investigated in diverse populations across the world. However, such obesity-associated mtDNA examinations are rarely conducted in Arab populations. We re-sequenced mtDNA displacement loop (D-loop) region of 395 Arab individuals of Kuwait. We categorized the individuals based on their BMI scores as obese (n=232; BMI ≥30 kg/m ), overweight (n=110; BMI ≥25 kg/m and
ISSN:1178-704X
1178-704X
DOI:10.2147/TACG.S198593