Parotid Gland Primary Amelanotic Malignant Melanoma

Amelanotic malignant melanoma (AMM) represents only 2%-8% of all malignant melanomas, and primary AMM of the parotid gland is very rarely diagnosed. This is the second case of primary AMM of the parotid gland in the literature. The aim of this report is to discuss our case and this rare entity. The detection of AMM is very complex because the pathology results can be confused with those for inflammatory processes and benign and malignant tumors. Immunohistochemical analysis of S100 protein and human melanoma black 45 (HMB45) analysis provides guidance in the differential diagnosis of AMM. In this report, we present a rapidly growing amelanotic malignant melanoma in the parotid gland. Examination of the patient and radiological studies showed no other lesions.