Anti-SMN autoantibodies in mixed connective tissue disease are associated with a severe systemic sclerosis phenotype

ObjectivesThe survival of motor neuron (SMN) complex has an essential role in the assembly of small nuclear ribonucleoproteins (RNP). Recent reports have described autoantibodies (aAbs) to the SMN complex as novel biomarkers in anti-U1RNP+ myositis patients. The aim of this study was to compare phen...

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Veröffentlicht in:	Rheumatic & musculoskeletal diseases open 2023-10, Vol.9 (4), p.e003431
Hauptverfasser:	El Kamouni, Hajar, S. Jalaledin, Darya, Albert, Alexandra, Hoa, Sabrina, Vo, Caroline, Bourré-Tessier, Josiane, Rich, Éric, Goulet, Jean-Richard, Koenig, Martial, Pérez, Gemma, Choi, May Y., Troyanov, Yves, Satoh, Minoru, Fritzler, Marvin J., Senécal, Jean-Luc, Landon-Cardinal, Océane
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune Diseases Autoimmunity Biomarkers Cardiac catheterization Connective Tissue Diseases Gastroesophageal reflux Kinases Lung diseases Lupus Medical imaging Myocarditis Proteins Pulmonary hypertension Regression analysis Rheumatology Scleroderma Scleroderma, Systemic Ultrasonic imaging
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Zusammenfassung:	ObjectivesThe survival of motor neuron (SMN) complex has an essential role in the assembly of small nuclear ribonucleoproteins (RNP). Recent reports have described autoantibodies (aAbs) to the SMN complex as novel biomarkers in anti-U1RNP+ myositis patients. The aim of this study was to compare phenotypic features of anti-U1RNP+ mixed connective tissue disease (MCTD) patients with and without anti-SMN aAbs.MethodsA retrospective MCTD cohort was studied. Addressable laser bead immunoassay was used to detect specific anti-SMN aAbs with
ISSN:	2056-5933 2056-5933
DOI:	10.1136/rmdopen-2023-003431