Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edema

AIM: To evaluate the efficacy of intravitreal injection of ranibizumab combined with macular grid photocoagulation for diabetic macular edema. METHODS: In this prospective cohort study, total 78 patients(101 eyes)diagnosed with diabetic macular edema in Dongguan People's Hospital from October 2016 to December 2018 were randomly divided into two groups. 40 patients(52 eyes)were in combination therapy group and 38 patients(49 eyes)were in monotherapy group. The changes of best corrected visual acuity(BCVA), central retinal thickness(CRT)and frequency of injections in two groups were compared after 12mo follow-up.RESULTS: At the end of 12mo follow up, the BCVA(0.44±0.22 vs 0.55±0.23)and CRT(335.3±65.9μm vs 370.4±84.4μm; P