Preliminary Study Results of Native Mongolian Inonotus Obliquus Extracts in Alloxan-Induced Diabetic Rats

Objectives: We aimed to investigate the morphological changes and clinical chemistry panel of alloxan-induced diabetic rats for the treatment groups of ethanol or aqueous extracts of Mongolian natural Inonotus obliquus. Methods: Wistar albino rats (n = 80) were randomly assigned into four groups: 1....

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Veröffentlicht in:Central Asian journal of medical science 2020-12, Vol.6 (4), p.255-261
Hauptverfasser: Delgersaikhan, Nyamsurendejid, Odkhuu, Erdenezaya, Namkhai, Ulzii-Orshikh, Batnasan, Galindev, Samdan, Enkhbaatar, Sundui, Enebish, Dorjkhuu, Amgalanbaatar, Aldartsogt, Dolgorsuren, Amgalanbaatar, Avirmed
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Sprache:eng
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Zusammenfassung:Objectives: We aimed to investigate the morphological changes and clinical chemistry panel of alloxan-induced diabetic rats for the treatment groups of ethanol or aqueous extracts of Mongolian natural Inonotus obliquus. Methods: Wistar albino rats (n = 80) were randomly assigned into four groups: 1. Healthy control group, 2. Untreated diabetic group, 3. Diabetic group treated with Inonotus obliquus (500 mg/kg per day) water extract, 4. Diabetic group with Inonotus obliquus (500 mg/kg per day) ethanol extract. Diabetes was induced by alloxan 150 mg/kg (single intraperitoneal injection) in the diabetic groups. Results: Both water and ethanol extract of Inonotus obliquus reduced the blood glucose level of diabetes at 48 h after treatment. Histologic and morphology examinations showed that water extracts of Inonotus obliquus alleviated the damage to pancreas tissues in alloxan diabetic rats. Conclusions: We postulate that simple ethanol and water extracts of natural Mongolian Inonotus obliquus have an antihyperglycemic effect that enhances islet cell function in alloxan-induced diabetic rats. The extracts of Mongolian natural Inonotus obliquus are easily producible at low cost and should be further explored as a treatment for diabetes.
ISSN:2413-8681
2414-9772
DOI:10.24079/cajms.2020.12.007