Estimated glucose disposal rate is associated with retinopathy and kidney disease in young people with type 1 diabetes: a nationwide observational study

The aim of this study was to investigate the association between estimated glucose disposal rate (eGDR), a proxy for insulin resistance, and retinopathy or kidney disease, i.e. micro-, or macroalbuminuria, in young individuals with type 1 diabetes (T1D). Using data from the Swedish pediatric registr...

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Veröffentlicht in:	CARDIOVASCULAR DIABETOLOGY 2023-03, Vol.22 (1), p.61-61, Article 61
Hauptverfasser:	Linn, Wedén, Persson, Martina, Rathsman, Björn, Ludvigsson, Johnny, Lind, Marcus, Andersson Franko, Mikael, Nyström, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Albuminuria Blood Glucose Blood pressure Body mass index Cardiac and Cardiovascular Systems Child Cohort analysis Creatinine Dextrose Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - epidemiology Diabetic retinopathy Estimated glucose disposal rate (eGDR) Female Glucose Humans Hypertension Insulin Insulin Resistance Kardiologi Kidney disease Kidney Diseases Medicin och hälsovetenskap Metabolic disorders Metabolic syndrome Observational studies Pediatrics Registration Retinal Diseases - complications Retinopathy Type 1 diabetes Type 2 diabetes Young Adult Young adults
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Zusammenfassung:	The aim of this study was to investigate the association between estimated glucose disposal rate (eGDR), a proxy for insulin resistance, and retinopathy or kidney disease, i.e. micro-, or macroalbuminuria, in young individuals with type 1 diabetes (T1D). Using data from the Swedish pediatric registry for diabetes (SweDiabKids) and the registry for adults (NDR), all individuals with T1D with a duration of diabetes of less than 10 years between 1998 and 2017 were included. We calculated the crude incidence rates with 95% confidence intervals (CIs) and used multivariable Cox regression to estimate crude and adjusted hazard ratios (HRs) for two cohorts: retinopathy cohort or kidney disease cohort, stratified by eGDR categories:
ISSN:	1475-2840 1475-2840
DOI:	10.1186/s12933-023-01791-x